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Charles Pak

Professor
Center for Mineral Metabolism & Clinical Research | Internal Medicine
Neuren Pharmaceuticals
Australia

Biography

After earning his M.D. and completing his internship and residency in Internal Medicine at the University of Chicago, he left for the NIH in 1963. In 1965, he joined Dr. Frederic Bartter as a senior investigator of the Endocrinology Branch of the National Heart and Lung Institute. Since 1972, he was recruited to Dallas to establish the General Clinical Research Center and to head a new division in Mineral Metabolism at University of Texas Southwestern Medical Center at Dallas. Currently he holds the Distinguished Chair in Mineral Metabolism and is Professor of Internal Medicine and Director of the Center for Mineral Metabolism and Clinical Research. Throughout his career, Dr. Pak has devoted himself to the study of kidney stones and osteoporosis. He has developed three FDA approved orphan drugs for kidney stones, elucidated metabolic causes for stone formation, and devised a multi-test kit for individuals at risk for forming kidney stones. During the past 15 years, he has concentrated on efforts to find an effective calcium supplement and safe use of fluoride. Recently, he established a national training program in clinical research for young physicians. Dr. Pak has published over 500 scientific articles. In 1987, he received the Distinguished Contribution Award from the American Urological Association. In 1988 he received the United States Public Service Award for Exceptional Achievement in Orphan Products Development and the Bartter Award from the American Society for Bone and Mineral Research. He was the 1992 recipient of the Distinguished Alumni Award from the University of Chicago. In 1996, he obtained the Commissioner¿s Citation from the FDA.

Research Interest

Endocrinology Kidney stones Mineral Metabolism Osteoporosis

Publications

  • Cloning and characterization of the human soluble adenylyl cyclase Geng W, Wang Z, Zhang J, Reed BY, Pak CY, Moe OW Am J Physiol Cell Physiol Summer 2005 288:6 C1305-C1316

  • Reduction in normalized bone elasticity following long-term bisphosphonate treatment as measured by ultrasound critical angle reflectometry Richer E, Lewis MA, Odvina CV, Vazquez MA, Smith BJ, Peterson RD, Poindexter JR, Antich PP, Pak CY Osteoporosis Int Fall 2005 16:11 1384-1392

  • Prevention of thiazide-induced hypokalemia without magnesium depletion by potassium-magnesium citrate Odvina CV, Mason RP, Pak CYC American Journal of Therapeutics 2006 13 101-108

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