Dr. Murat Saparbaev

Biography

  DNA Repair Group leader Dr. Murat Saparbaev   10 major publications of Dr SAPARBAEV group Talhaoui, I., Shafirovich, V., Liu, Z., Saint-Pierre, C., Akishev, Z., Matkarimov, B.T., Gasparutto, D., Geacintov, N.E. and SAPARBAEV, M. (2015) Oxidatively Generated Guanine(C8)-Thymine(N3) Intrastrand Cross-links in Double-stranded DNA Are Repaired by Base Excision Repair Pathways. J. Biol. Chem., 290, 14610-14617. Talhaoui, I., Couve, S., Gros, L., ISHCHENKO, A.A., Matkarimov, B. and SAPARBAEV, M.K. (2014) Aberrant repair initiated by mismatch-specific thymine-DNA glycosylases provides a mechanism for the mutational bias observed in CpG islands. Nucleic Acids Res., 42(10), 6300-6313. Prorok, P., Alili, D., Saint-Pierre, C., Gasparutto, D., Zharkov, D.O., ISHCHENKO, A.A., Tudek, B. and SAPARBAEV, M.K. (2013) Uracil in duplex DNA is a substrate for the nucleotide incision repair pathway in human cells. Proc. Natl. Acad. Sci. U.S A., 110(39), E3695-3703. Talhaoui, I., Couve, S., ISHCHENKO, A.A., Kunz, C., Schär, P. and SAPARBAEV, M. (2013) 7,8-dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by E. coli and human mismatch-specific uracil/thymine-dna glycosylases. Nucleic Acids Res. 41(2), 912-923. Couve-Privat, S., Mace-Aime, G., Rosselli, F. and SAPARBAEV, M.K. (2009) Human oxidative DNA glycosylase NEIL1 excises psoralen-induced interstrand DNA cross-links in the three-stranded DNA structure. J. Biol. Chem. 284, 11963-11970. Couve-Privat, S., Mace, G., Rosselli, F., and SAPARBAEV, M. K. (2007) Psoralen-induced DNA adducts are substrates for the base excision repair pathway in human cells, Nucleic Acids Res 35, 5672-5682. ISHCHENKO, A.A., Deprez, E., Maksimenko, A., Brochon, J.C., Tauc, P., and Saparbaev, M.K. (2006) Uncoupling of the base excision and nucleotide incision repair pathways reveals their respective biological roles. Proc. Natl. Acad. Sci. U. S. A., 103, 2564–2569. Gros, L.*, ISHCHENKO, A.A.*, Ide, H., Elder, R.H. and SAPARBAEV, M. (2004) The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway. Nucleic Acids Res., 32, 73-81. Gros, L., Maksimenko, A.V., Privezentzev, C.V., Laval, J. and SAPARBAEV, M.K. (2004) Hijacking of the human alkyl-N-purine-DNA glycosylase by 3,N4-ethenocytosine, a lipid peroxidation induced DNA adduct. J. Biol. Chem. 279, 17723-17730. ISCHENKO, A.A. and Saparbaev, M.K. (2002) Alternative nucleotide incision repair pathway for oxidative DNA damage. Nature, 415, 183-187.  

Research Interest

  DNA Repair