Prof. Filippo Rosselli
Group leader
FANC/BRCA signalling pathway and Cancers
Gustaveroussy
France
Biography
Prof. Filippo Rosselli Group leader FANC/BRCA signalling pathway and Cancers. Our interests include characterisation of cellular and molecular response to exposure to DNA damaging agents or disrupting replication. In our work, we use as main model cells from Fanconi anaemia (FA) patients. FA is a rare recessive genetic syndrome presenting haematologic failure, predisposition to cancer and genetic instability. The syndrome is genetically heterogeneous, caused by bi-allelic inactivating mutations in at least 17 different genes. The biochemical activity and the molecular role of the FANC proteins are still incompletely understood. However, it is clear that the FANC proteins are part of a complex network involving components of chromatin (H2AX, BRG1), signalling proteins (ATM, ATR) and proteins dedicated to DNA repair, including RPA, the RAD50 -MRE11-NBS1 complex, BLM, ERCC1/XP-F and RAD51. The major biological, widely recognised, role of the FANC pathway is to participate in the maintenance of the stability of replication forks allowing their restart following their arrest caused by the presence of a lesion in the DNA.
Research Interest
DNA repair
