Michael Gotthardt

Publications

• Granzier, H., Radke, M., Royal, J., Wu, Y., Irving, T.C., Gotthardt, M., Labeit, S. (2007) Genomic and functional analysis of avian, murine, and human titin supports splice diversity as an important mechanism for regulating biomechanics of striated muscle. Am J Physiol Regul Integr Comp Physiol 293: R557–R567

• Home > Aus- & Weiterbildung > PhD > Michael Gotthardt Michael Gotthardt Max-Delbrück-Center for Molecular Medicine (MDC) Robert-Rössle-Str. 10 13125 Berlin, Germany Phone: +49 30 9406 2245 FAX: +49 30 9406 3382 gotthardt@mdc-berlin.de http://titin.mdc-berlin.de Objectives The basic focus of my research is to elucidate how biomechanical input is converted into biochemical signals and how it applies to heart and skeletal muscle disease. We use a proteomics and biomechanics approach to investigate the contribution of the sarcomeric protein titin and the tight junction protein CAR to cardiac function and disease. I have a strong interest to increase the translational aspect in the PhD curriculum of the MDC with the “TransCard” program based on my training as a physician and scientist, my research interest in translational medicine, and my long-term collaboration with clinical partners on campus, in Germany, and abroad. My teaching experience covers anatomy, physiology, and molecular medicine. Professional experience Associate Professor |MDC / UniversitätsmedizinBerlin January 2007 - present Molecular Cardiology, mechanotransduction, electrophysiology Assistant Professor |MDC/UniversitätsmedizinBerlin April 2004 – December 2006 Functional Genomics - analysis of Titin and CAR-Knockouts (KO) Junior Group leader |MDC April 2002 – April 2004 Neuromuscular and Cardiovascular Cell-Biology - Sarcomere assembly Research Assistant Prof. |Washington State Univeristy October 2001 – present (currently adjunct position) Analysis of Titin KO mice, biomechanics Clinical Elective |KlinikumBuch/Harvard Medical School June 1995 – May 1996 Obstetrics, pediatrics, surgical oncolocy, genetics, metabolism, endocrinology Tutor |University Heidelberg Medical School June 1995 – May 1996 Dept. of Anatomy and Cell-Biology – Macroscopic Anatomy Education/ Training UT Southwestern Medical Center at Dallas Fellow in the Department of Molecular Genetics, 1997-2001 Max-Delbrück-Center for Molecular Medicine in Berlin-Buch and Franz-Volhard-Clinic MD thesis in virology (highest honors) and fellow in Cardiology; 1997 Heidelberg and Humboldt University Berlin Medical Schools Medicine - clinical training; 1991-96 - MD degree Heidelberg University Medical School Medicine - preclinical training; 1989-91 Publications 2008 Raddatz K, Albrecht D, Hochgräfe F, Hecker M, Gotthardt M. A proteome map of murine heart and skeletal muscle. Accepted in Protecomics 2-2008 2007 Jansen P., Giehl K., Nyengaard J.R., Teng K., Lioubinski O., Sjoegaard S.S., Breiderhoff T., Gotthardt M., Lin F., Eilers A., Petersen C.M., Lewin G.R., Hempstead B.L., Willnow T.E., Nykjaer A. (2007) Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. Nat Neurosci. 10(11):1449-57.

• Raddatz K, Albrecht D, Hochgräfe F, Hecker M, Gotthardt M. A proteome map of murine heart and skeletal muscle. Accepted in Protecomics 2-2008

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