Giustiniano Mariateresa
Pharmaceutical Chemistry Researcher
Department of Pharmacy
University Federico II
Italy
Biography
December 2016 to Today: Determined Time Researcher (RTD-A) at the Department of Pharmacy of the University of Naples Federico II. February 2016 - December 2016: Research Check for a project titled "Identification of new molecular targets for chemo-resistant tumors and discovery of new chemical entities with antitumor properties." November 2015-January 2016: Research Fellow for a project titled "Structural modifications of peptides in smart packaging functionalization". October 2012-October 2015: Research Check for a project titled "Mitochondrial Medicine and drug discovery. Design and Synthesis of new bax, bak, mdm-2 and mdm-4 modulators ". February 2011-February 2012: Research Fellow for a project titled "Design and Synthesis of new DNA G-quadruplex binders". December 2010: Ph.D. degree in Pharmacy Science at the Pharmacy Department of the University of Naples Federico II (XXIII Cycle), Tutor: prof. E. Novellino. January-December 2010 : Visiting Fellow in the laboratories of prof. Jieping Zhu at the Institut de Chimie des Substances Naturelles-CNRS in Gif-sur-Yvette, Paris. April-November 2009 : Visiting Fellow in the laboratories of prof. Gian Cesare Tron at the Department of Pharmaceutical Sciences, University of Eastern Piedmont, Novara. July 2007: Bachelor's Degree in Pharmaceutical Chemistry and Technology at the Department of Pharmacy of the University of Naples Federico II, Tutor: prof. MV Diurnal.
Research Interest
Study of new anticancer drugs; Synthesis of bioactive heterogeneous compounds; Study and application of multi-component reactions for the development of biologically active molecule libraries; Diversity Oriented Synthesis (DOS) and Combining Chemistry; Study of privileged structures in the pharmaceutical field; Application of spectroscopic and spectrometric techniques for characterization of synthesized molecules.
Publications
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Z- Chloroximes and Nitrile Imines as new fuels for the discovery of new isocyanide-based multicomponent reactions. Giustinian M., Novellino E., Tron GC Synthesis 2016, 48 , 2721-2731.
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An effective synthesis of 1-arylindazole-3-carboxamides using nitrile imines, isocyanides and 2-hydroxymethylbenzoic acid followed by chemoselective Buchwald-Hartwig intramolecular cyclization. Giustiniano M., * Mercalli V., Novellino E., Tron GC * RSC Adv. 2016, 6 , 34916-34920.
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To each his own: isonitriles for all flavors. Functionalized isocyanides as valuable tools in organic synthesis. Giustiniano M., Basso A., Mercalli V., Massarotti A., Novellino E., Tron GC, Zhu J. Chem. Soc. Rev. 2017, 46 , 1295-1357.
