La Pietra Valeria
Pharmaceutical Chemistry Researcher
Department of Pharmacy
University Federico II
Italy
Biography
2007 Degree in Pharmaceutical Chemistry and Technology achieved on 10/07/2007 with 110/110 vote and praise at l 'University of Naples' Federico II "discussing the thesis titled:" TOSSIC EVENTS OF THE ESTATE 2005 LONG COSTA LIGURE. IDENTIFICATION OF THE TOSSINE RESPONSIBLE WITH A NEW METHOD LC / MS "(Rapporteur: Prof. Patrizia Ciminiello). 2010 Ph.D. in Medicine Science, XXIII cycle at the University of Naples "Federico II". He held a first part of the research activity at the Department of Pharmacy and Toxicology Chemistry at the Faculty of Pharmacy of Naples under the supervision of Prof. Marinelli while the second part of the PhD was held at the laboratories of Prof. William Jorgensen at the Starling Chemistry Department at Yale University, New Haven, CT, USA. He received his Ph.D. degree on 17/12/2010, discussing the thesis titled "Identification of Novel Molecular Scaffolds for the Design of MMP-13 Inhibitors through Virtual Screening Methods" 2011 Winner of a PostDoc Stock Exchange in IIT in Genoa to carry out research at the Department of Pharmaceutical and Toxicology Chemistry at the Faculty of Pharmacy of Naples "Federico II" 2012 Winner of a three-year Research Certificate at the Department of Pharmacy of Naples "Federico II" under the project: "Innovative computational methodologies for the identification and development of new active proapoptotic agents on mitochondrial targets" 2017 From December 30, 2016, he won a competition for a position as a time researcher L. 240/10 type A at the Department of Pharmacy of the University of Naples Federico II, scientific / disciplinary sector CHIM-08
Research Interest
Optimization of organic molecules that act as dual inhibitors of ADAM10 / TACE as new drugs capable of blocking "ALCAM Shedding" in order to inhibit the motility and invasiveness of epithelial ovarian cancer cells. - Development of organic and peptide-mimetic molecules as BAX activators, and identification of MDM-2 and -4 inhibitors, in order to induce apoptosis in chemio-resistant tumors.
Publications
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"Best Matching Protein Conformations and Docking Programs for a Virtual Screening Campaign Against SMO Receptor." Amendola G., Di Maio D., Pietra V., Cosconati S. Mol Inform . 2016, 35, 340-9.
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"Exploring the N-Terminal Region of CXC Motif Chemokine 12 (CXCL12): Identification of Plasma-Stable Cyclic Peptides As Novel, Potent CXC Chemokine Receptor Type 4 (CXCR4) Antagonists." By Maro S., Trotta AM, Brancaccio D. , Di Leva FS, Pietra V., Ierano C., Napolitano M., Portella L., D'Alterio C., Sicilian RA, Sementa D., Tomassi S., Carotenuto A., Novellino E., Scala S. , Marinelli L. J Med Chem. 2016, 59, 8369-80 (Cit. 1)
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"Bax activation blocks self-renewal and induces apoptosis of human glioblastoma stem cells." Daniele S., Pietrobono D., Costa B., Giustiniano M., Pietra V., Giacomelli C., La Regina G., Silvestri R., Taliani S., Trincavelli ML, Da Settimo F., Novellino E., Martini C., Marinelli L. ACS Chemical Neuroscience 2017, Epub ahead of print
