Randazzo Antonio
Professor of Pharmaceutical Chemistry
Department of Pharmacy
University Federico II
Italy
Biography
1995 Degree in Pharmaceutical Chemistry and Technology , University of Naples "Federico II". Experimental thesis : "Synthesis of solid phase analogous polynucleotides and their applications in antisense technology". 1999 Doctoral Program in Pharmacologically Active Natural Substances , XI Cycle (1995-1998), Department of Natural Chemistry Department, Faculty of Pharmacy, University of Naples "Federico II" Thesis : "New secondary metabolites from porphyria as models for the development of anti-inflammatory and anti-inflammatory drugs".
Research Interest
The research activity of prof. Randazzo focused primarily on the study of alternative DNA structures, such as four-filament structures called G-quadruplex. In particular, in recent years, he focused his attention on the study of the interaction of small organic molecules with such DNA structures, with both computational and spermatic approaches, in order to discover potent drugs with different therapeutic applications.
Publications
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Discovery of the first dual G-triplex/G-quadruplex stabilizing compound: a new opportunity in the targeting of G-rich DNA structures?
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Lead Discovery of Dual G-Quadruplex Stabilizers and Poly(ADP-ribose) Polymerases (PARPs) Inhibitors: A New Avenue in Anticancer Treatment
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Structure-activity relationship of the exopolysaccharide from a psychrophilic bacterium: A strategy for cryoprotection
