Sautebin Lidia

Biography

Ordinary Professor of Pharmacology, Department of Pharmacy, University of Naples Federico II. Coordinator of the 2nd level Master in "Preclinical and Clinical Development of Medication and Post-Marketing Monitoring", Department of Pharmacy, University of Naples Federico II (2012-2016). Head of Laboratory "Gender Pharmacology in the Inflammatory Process", Department of Pharmacy, University of Naples Federico II. Head of the Cosmetovigilance Laboratory, Department of Pharmacy, University of Naples Federico II. Component, as a pharmacologist, of the Ethics Committee of the Hospitality Company "Antonio Cardarelli" of Naples. (2004-2009). Representative of the Italian Society of Pharmacology, for the "CEN / ISSS Workshop on Pharmaceutical Compounding E-Codification Methodology (WS / PCEC)", Brussels (2007-2008). Component of the working group for the creation of a Cosmetovigilance system (Ministry of Health, Department of Innovation, Directorate General of Drugs and Medical Devices) 2006-2007; 2009-2010). Component of the "Permissible Limits for Heavy Metals in Cosmetic Products" Working Group (Ministry of Health, Department of National Programming and National Healthcare, Directorate General of Medical Dispensers, Pharmaceutical Service and Cure, 2011). External expert, since 2011, for the Ministry of Health (Department of Innovation, Directorate General of Drugs and Medical Devices) in the working group "Sub-working group Serious Undesirable Effects (SUE)" working within the activities of the Surveillance Authorities of the European Cosmetics Market (PEMSAC). The SUE Working Group is a subgroup of the Working Group on Cosmetic Products at the European Commission in Brussels. It is also part of the PEMSAC subgroup "Market Surveillance". He spent his research abroad at the Pasteur Institute in Paris (Department of Radioimmunology Analyzes, Prof. F. Dray, INSERM U207) in 1978 and at the Karolinska Institutet in Stockholm (1981-1982, 1989), Department of Chemistry physiological course directed by Prof. Bengt Samuelsson, Nobel for Physiology and Medicine in 1982. Academic career Professor Lidia Sautebin graduated in 1975 in Biology with praise at the University of Milan. Since 1976 he has attended the Institute of Pharmacology and Pharmacognosy of the Faculty of Pharmacy of the University of Milan as a fellow and since 1980 as a confirmed researcher. In 1985 he moved to the Department of Experimental Pharmacology at the Faculty of Pharmacy (current Department of Pharmacy) of the University of Naples Federico II, where he became Associate Professor of Pharmacology (SSD BIO14) in 1998, 2010 and has been an ordinary professor since November 2013. The research activity, in collaboration with Italian researchers (University of Perugia, University of Messina, University of Rome, University of Siena) and foreigners (Karolinska Institutet in Stockholm, University of Jena, University of Frankfurt, Tubinga University) is documented by more than 120 publications on major international journals and numerous (more than 100) participations at national and international congresses, also by invitation. Most significant publications Sex-biased eicosanoid biology: impact on sex differences in inflammation and consequences for pharmacotherapy. Pace S, Sautebin L, Werz O. Biochem Pharmacol. 2017 Sex differences in prostaglandin biosynthesis in neutrophils during acute inflammation. Pace S, Rossi A, Krauth V, Dehm F, Troisi F, Balance R, Weinigel C, Rummler S, Werz O, Sautebin L. Sci Rep. 2017 Jun 19; 7 (1): 3759 In vivo sex differences in leukotriene biosynthesis in zymosan-induced peritonitis. Rossi A, Pergola C, Pace S, RÃ¥dmark O, Werz O, Sautebin L. Pharmacol Res. 2014 Sep; 87: 1-7. Evaluation of cosmetic product exposures reported to the Milan Poison Control Center, Italy from 2005 to 2010. Ruggiero S, Moro PA, Davanzo F, Capuano A, Rossi F, Sautebin L. Clin Toxicol 2012 Dec; 50 (10): 902-10 . Testosterone suppresses phospholipase D, causing sex differences in leukotriene biosynthesis in human monocytes. Pergola C, Rogge A, Dodt G, Northoff H, Weinigel C, Barz D, RÃ¥dmark O, Sautebin L, Werz O. FASEB J. 2011 Oct; 25 (10): 3377-87 Drug safety information through the Internet: the experience of an Italian website. Polymer G, Russian A, Catania MA, Aiello A, Oteri A, Trifir G, Calapai G, Sautebin L, Iacobelli M, Caputi AP. Drug Saf. 2009; 32 (3): 245-53. Notification of undesirable effects of cosmetics and toiletries. Sportiello L, Cammarota S, Portu S, Sautebin L. Pharmacol Res. 2009 Feb; 59 (2): 101-6 ERK-mediated regulation of leukotriene biosynthesis by androgens: a molecular basis for gender differences in inflammation and asthma. Pergola C, Dodt G, Rossi A, Neunhoeffer E, Lawrenz B, Northoff H, Samuelsson B, RÃ¥dmark O, Sautebin L, Werz O. Proc Natl Acad Sci US A. Dec 16; 105 (50): 19881-6. DIDACTIC AND SCIENTIFIC ACTIVITIES Teaching activity. Since 1991, he has been in charge of teaching pharmacological disciplines for Pharmacy Faculty degree programs including Pharmacovigilance. At present he has the teaching role of General Pharmacology and Pharmacotherapy for the PhD degree in Pharmaceutical Chemistry and Technology. He has also been a lecturer at the School of Specialization in Pharmacology; of the School of Specialization in Science and Technique of Medicinal Plants, of the Complexion in Medicinal Plants and of the Master of Science in Farmacoeconomics. He teaches the Pharmacovigilance Course for the Hospitality Pharmacy Specialization School as well as a Master of Level II Master in "Preclinical and Clinical Development of Medication and Post-Marketing Monitoring" activities at the Faculty of Pharmacy (now Pharmacy Department) of the University of Naples Federico II (2012-2016). From 1976 to 1982, and from 1981 to 2002, seminars for the Pharmacology and Toxicology Schools of the Pharmacy Faculty of the University of Milan and, most recently, for other Italian Universities such as the 2nd level Master's degree in " Evaluation of the Safety of Cosmetic Products "of the Faculty of Pharmacy of the University of Siena. He is organizing training and updating courses in pharmacology, including pharmacovigilance and cosmetic vigilance, and as a lecturer at training courses organized by the Ministry of Health, the Higher Institute of Health and Regions (Campania, Umbria and Veneto). and from 1981 to 2002 seminars for the Pharmacology and Toxicology Schools of the Faculty of Pharmacy of the University of Milan and, more recently, for other Italian Universities such as the 2nd level Master in "Evaluation of the Safety of Cosmetic Products" of the Faculty of Pharmacy of the University of Siena. He is organizing training and updating courses in pharmacology, including pharmacovigilance and cosmetic vigilance, and as a lecturer at training courses organized by the Ministry of Health, the Higher Institute of Health and Regions (Campania, Umbria and Veneto). and from 1981 to 2002 seminars for the Pharmacology and Toxicology Schools of the Faculty of Pharmacy of the University of Milan and, more recently, for other Italian Universities such as the 2nd level Master in "Evaluation of the Safety of Cosmetic Products" of the Faculty of Pharmacy of the University of Siena. He is organizing training and updating courses in pharmacology, including pharmacovigilance and cosmetic vigilance, and as a lecturer at training courses organized by the Ministry of Health, the Higher Institute of Health and Regions (Campania, Umbria and Veneto). for other Italian Universities such as the 2nd level Master in "Evaluation of the Safety of Cosmetic Products" of the Faculty of Pharmacy of the University of Siena. He is organizing training and updating courses in pharmacology, including pharmacovigilance and cosmetic vigilance, and as a lecturer at training courses organized by the Ministry of Health, the Higher Institute of Health and Regions (Campania, Umbria and Veneto). for other Italian Universities such as the 2nd level Master in "Evaluation of the Safety of Cosmetic Products" of the Faculty of Pharmacy of the University of Siena. He is organizing training and updating courses in pharmacology, including pharmacovigilance and cosmetic vigilance, and as a lecturer at training courses organized by the Ministry of Health, the Higher Institute of Health and Regions (Campania, Umbria and Veneto).

Research Interest

1. the inflammatory process, its etiopathogenesis, the molecular and cellular mechanisms that regulate it and the anti-inflammatory activity are both synthesis and natural origin molecules . In this topic, the following topics were discussed: a) the metabolic pathway of arachidonic acid / prostaglandins / leukotrienes and, subsequently, that of L-arginine / nitrogen oxide, whose metabolites were studied the pathophysiological role as well as mutual interactions in regulating the inflammatory process; b) the mechanism of action of glucocorticoids as anti-inflammatory drugs; c) of the study of anti-inflammatory activity of synthesis and natural origin molecules with particular regard to inhibitors of the "five lipoxygenase activating protein", prostaglandin E2 microsomal-1 synthesis, 5-lipoxygenase (5-LO) and cyclooxygenase 1/2 (COX) in order to identify potential selective anti-inflammatory drugs and thus lack the side effects of those currently in use; d) (male / female) influence in the regulation of 5-LO and mutually modulating with other enzymes involved in inflammation with particular interest in regulating the activity of these enzymes and their inhibitors in order to evaluate a possible dependent anti-inflammatory therapy by sex. In particular, it has been shown that in the polymorphonucleates and male and female male monocytes subcellular distribution of 5-LO and subsequent production of leucotrienes (LT) were closely related to the presence of testosterone. More recently, LT (greater in females) sex dependence has also been demonstrated in an in vivo model of acute inflammation, zymotic-induced peritonitis in rat and carrageenin-induced pleuritis in rat. In the same experimental models, a greater production of prostaglandins (E2 and I2) in the male than the female due to a higher expression of CO 2 and the phenomenon of shunting of arachidonic acid, common substrate for LT and PG . The different production of LT and PG could explain the different incidence of inflammatory disease in humans and women. He has collaborated and collaborated with Italian and foreign researchers (Prof. Bengt Samuelsson and Prof. Olof Radmark of the Karolinska Institutet in Stockholm, Sweden), Prof. Oliver Werz of Jena University, Prof. Steinhilber of the University of Jena, University of Frankfurt and other teachers from the University of Tuebingen, Germany. 2. The development of methodologies p er the dosage of endogenous compounds and substances having a pharmacological / toxicological activity. For most of the researches, especially during the period spent at the Institute of Pharmacology and Pharmacognosy of the Faculty of Pharmacy of the University of Milan, the new analytical procedures developed for the quantitative / quantitative determination of arachidonic acid metabolites in different biological systems and the experience gained in the field of innovative analytical methodologies acquired during stays abroad. During this period, some studies have been carried out on the development of analytical techniques to determine the pharmacokinetics of some of the then innovative medication preparations (slow release preparations) or to determine levels of food contaminants (estrogen in childhood preparations). 3. the supervision and, in particular, of: ( a) the assessment of the safety of use of cosmetic products, the risk of use being both improper and improper of such products and of counterfeit products; b) the issues associated with the notification, validation and evaluation of undesirable effects on cosmetics; c) the role of Antivelen Centers in the control of toxicity by exposure to cosmetics; (e) the role of healthcare professionals and end-users (consumers and practitioners in the cosmetic sector) in the reporting of undesirable effects on cosmetics. In the framework of these researches he collaborated and collaborated with Italian Authorities (Ministry of Health and Higher Institute of Health) and European (European Commission) for the establishment of a system of cosmetovigilance and for the detection of undesirable effects on cosmetics. In particular: 1) participated from October 2006 to April 2007 at a series of meetings with the Ministry of Health on the establishment of a system of cosmetic watch meetings that continued from May 2009 to April 2010 (Department of Innovation, Directorate-General for Health Drugs and Medical Devices); 2) participated in the working group "permissible limits for heavy metals in cosmetic products" (Ministry of Health, Department of Programming and National Healthcare, Directorate General of Medical Dispensers, of the Pharmaceutical and Cure Services, 2011); 3) is an external expert from 2011 for the Ministry of Health (Department of Innovation, Directorate General of Drugs and Medical Devices) in the working group "Sub-working group Serious Undesirable Effects (SUE)" working in the field of European Cosmetic Market Surveillance Authority (PEMSAC). The SUE Working Group is a subgroup of the Working Group on Cosmetic Products at the European Commission in Brussels. It is also part of the PEMSAC subgroup "Market Surveillance". It also deals with training and information for healthcare professionals and the cosmetics industry as well as for consumers regarding legislation, The entire research activity, which is carried out, as already reported, in collaboration with both national and international groups, is documented by more than 120 publications on major international journals and numerous (more than 100) participations at national and international congresses even on invitation. He is also the author of chapters in volumes and acts of international and national congresses and books and organizers of national and international conferences.