Maria Grazia Cabiddu
Researcher
Department of Chemical Sciences
University of Cagliari
Italy
Biography
He graduated from class in Cagliari, at Liceo Ginnasio "GM Dettori" in July 1984, bringing the 60/60 vote. He graduated in Chemistry at the University of Cagliari on 16/11/1990 with a vote of 110/110 and praise, discussing an undergraduate thesis, performed largely by the Department of Bioorganic Chemistry at the University of Pisa , entitled "Reactivity of 10,11-oxide of 2-Methyl-5 H -Dibenzo [ a, d ] cycloheptene in hydrolysis catalyzed by acids and by microsomal epoxide hydrolase", subsequently published in the Italian Journal of Chemistry (123, 1993 87 ). In 1991 he won a place for the Doctoral Program in Chemistry Sciences (VIIth cycle, Consortium Sassari, Cagliari, Pisa) and its scholarship. He holds the title of Ph.D. in "Chemistry Sciences" on 18/10/1995 with a thesis titled "Conservation of Cultural Heritage. Deterioration and Protection of Carbonate Matrix Surfaces ". He won for the academic year 1994/1995, at the University of Cagliari, a place for the finalization course on the "Study of Structure Structures-Molecular Biology Activities" study and its scholarship. For the academic years 1995/1996, 1996/1997, 1997/1998 at the University of Cagliari, a research contract in the "Chemistry and Energy" area under the title "Preparation, study of properties and applications of intermediate molecules precursors of phase transfer catalysts, proteins and biological activity molecules. " In February 1999, he was awarded a technical assistant (seventh functional qualification) assigned to the C05X disciplinary scientific field - Organic Chemistry at the University of Cagliari. In October 1999, at the University of Cagliari, a researcher assigned to the disciplinary scientific field CHIM / 06 - Organic Chemistry During the 2001-2002 and 2002-2003 academic years, he was a lecturer on the course of "Environmental and Cultural Heritage Chemistry" for the Degree in Archaeological Heritage of the Faculty of Letters. During the three-year period 1999-2002 Prof. Franca Sotgiu joined the Chemistry Faculty of the Faculty of Science in the "Organic Chemistry Laboratory I". In the 2001-2002 academic year he was a professor of the "Organic Chemistry Laboratory II" course. Starting from the academic year 2002-2003 to 2009-2010 he was lecturer of the "Chemistry of Ether Compounds" course (3 cfu) for the three-year degree in Chemistry of the Faculty of Science MMFFNN. During the academic years 2008-2009 and 2009-2010 he was a professor of the course "Chemistry of Ether Compounds" (4 cfu) for the MSc in Chemical Sciences at the Faculty of Science MMFFNN. From the academic year 2003-2004 he is a professor of the "Organic Chemistry" (6 cfu) course for the three-yearly PhD studies in Experimental Biology and Applied Bioecology and is currently in the new three-year degree in Biology at the Faculty of Biology and Pharmacy. In the academic year 2016-2017 he is also lecturer of the course "Organic Chemistry" (6 cfu) for the three-year degree in Natural Sciences. She teaches tutoring for students working in research laboratories as graduates and / or graduates and is a correlator of various Degree theses. He has focused his research on topics related to the preservation of cultural goods and organic chemistry. With regard to the first point, dealt with during the Ph.D., he studied the degradation of carbonated matrix monuments exposed in polluted and non-marine environments, trying to elaborate new theories or validate old theories to formulate materials to block or slow down the deterioration processes. To this end, the investigations were carried out using various techniques, among which the most used were X-ray diffractometry, porosimetry by forced mercury intrusion or by nitrogen adsorption isotope, optical microscopy, optical microscopy scanning electron microscopy and energy dispersion spectrometer. The topic of organic chemistry was initiated during the thesis work that focused on the study of epoxide hydrolysis catalyzed by microsomal epoxide hydrolysis (mEH), an important enzyme involved in the detoxification of epoxides, often mutagenic compounds carcinogens, formed in the metabolic oxidation of xenobiotic compounds containing olefinic and aromatic functions. After the appointment as a researcher, he undertook the study of the regiochemistry of organolithic and superazional reaction reactions with the aim of polyfunctionalizing aromatic compounds containing ether, thioethero, sulfoxide, sulfonic, aminic, trifluoromethyl, halogen atoms with the same substituents different, to study the competitiveness of these functions in directing metal input and preparing heterogeneous compounds. He has dealt with the synthesis of new organic molecules with antiviral activity and is now engaged in synthesized functionalities for the production of biologically active organic and biochemical molecules of new binders and metallic complexes with biological activity and photoluminescence properties.
Research Interest
Organic Chemistry.
Publications
-
Exploration of the anti-enterovirus activity of a series of pleconaril / pyrodavir-like compounds 2017.
-
Novel propanamides as fatty acid amide hydrolase inhibitors. 2017
-
Competitive reactions between glutathione, cisplatin and copper-phenanthroline complexes 2017.