Lidia Ibba

Biography

Prof. LIDIA IBBA MANNESCHI, born in Grosseto on 11/12/1949, enrolled in the Degree Course in Biological Sciences of the Faculty of Mathematical, Physical and Natural Sciences at the University of Siena, A.A. 1968/69. During the last two years, she has attended the Microbiology Institute as an internal student while awaiting the graduation thesis. He graduated on 13/7/1972 discussing an experimental thesis titled "Plasmid Disinfection Probes following a 3 to 4-Benzophenene Effluent in E. Coli treated with EDTA", bringing the vote of 110/110 and the Praise. On 1/11/1972 he was awarded a biennial scholarship for didactic and scientific training at the Chair of Histology and General Embryology of the Faculty of Medicine and Surgery of the University of Siena. On 1/11/1974 he was awarded a four year contract (with DR No. 281 of 25/1/75) at the Chair of Histology and General Embryology of the Faculty of Medicine and Surgery of the University of Siena which was subsequently extended from 1/11/1978. On 1/8/1980, a university researcher has been appointed for the University of Siena Institute of Histology and Embryology at the Department of Medicine, Department of Medicine and Surgery at No. 71 of the Faculty of Medicine. On 26/7/1982 he graduated in Medicine and Surgery from the University of Florence, discussing a thesis titled "Role of Endoscopic Retrograde Backbone Chirurgia (ERCP) in the Diagnosis of Panic and Bacterial Pathology." Experience of 80 cases, bringing the vote of 110/110 and the Praise. He was appointed a representative of the university researchers at the Faculty Council of Medicine and Surgery at the Aa. aa. 1983/85 and in the Bachelor's Degree in Medicine and Surgery for aa. 1982/83 and for the 1985/87 two-year period.

Research Interest

1) Morphological and molecular study on synovium of patients with hemophilic arthropathy and patients with rheumatoid arthritis. 2) Study of molecules implicated in angiogenesis in skin biopsies obtained from patients with systemic sclerosis, and in vitro studies on sclerodermic patients isolated from microvascular endothelial cells. 3) Study of the involvement of cytokine molecules and their receptors in the pathogenesis of systemic sclerosis, and involvement of organs (skin, gastrointestinal tract, lung, placenta). 4) Study of the role of polymorphisms of genes involved in cellular apoptosis and angiogenesis in influencing susceptibility to scleroderma and modulation of its clinical manifestations. 5) Study of peripheral intestinal and peripheral joint alterations in the animal transgenic rat model for the HLA-B27 high-complex complex alleles and effects of anti-TNFalpha therapy on the onset and evolution of inflammatory disease chronic intestinal tract and peripheral arthropathy. 6) morphological and molecular study of the uPAR receptor and its role in the angiogenesis of microvascular endothelial cells isolated from skeletal carcinomas and healthy controls. 7) Ultrastructural and immunohistochemical study of changes in skin care of patients with systemic sclerosis in the different subsets and stages of the disease. 8) Structural and ultrastructural alterations of the pelvic myocardium of pressure and volume overload by electron microscopy (TEM) and confocal laser scanning microscopy (CLSM). 9) Ischemic-reperfusion syndrome in human skeletal muscle tissue and psychiatric muscle. 10) Enteric Nervous System in the Human Stomach and Human Colon with immunohistochemical methods for optical microscopy and CLSM. 11) Intestinal damage caused by polymicrobism in HIV + patients. 12) Lymphatic vessels in the skin and lower limbs of man and the mesenteric intestine of laboratory animals using traditional techniques of histology, immunohistochemical methods and TEM.