Fiorella Casamenti

Biography

Prof. Fiorella Casamenti was born in Seggiano (GR) on 10/05 / '52, resident in Florence at Via Bolognese n ° 5, 50129 Florence, graduated in Biological Sciences in 1976. From 1980 to 2001 he held the role of confirmed researcher at the Faculty of Medicine and Surgery of the University of Florence, in service at the Department of Preclinical and Clinical Pharmacology "Mario Aiazzi Mancini" of the same University. In 2001 Prof.ssa was the winner of comparative evaluation of second-grade professor for the BIO / 14 sector at TORINO -Fac- MEDICINE and SURGERY UNIVERSITY. Since 01/11/2001 she has served as Associate Professor at the Faculty of Medicine and Surgery of Florence in SSD BIO / 14 in service at the Department of Pharmacology of the same Faculty. Winner of scholarships (IBRO, Polish Academy of Sciences and CNR) with whom he worked abroad at neurofarmacology research laboratories (MAINZ, LIPSIA AND VARSAVIA). Several times as a speaker at National and International Congresses and often as an invited speaker and chairperson. He is co-author of 77 extensively published works on reviewed international journals, over 20 papers on international books and over 300 communications to national and international congresses. He is a referee for J. Neurochem., Neurosci. Lett., Restor. Neurol. Neurosci, Pharmacol. Res. And Neuropharmacology. He is a member of the Italian Society of Pharmacology (SIF), of the Italian Society of Neurosciences (SINS); of the Society for Neuroscience (SfN); of the Italian brain aging group (Airic). The teacher. has a regular teaching activity at the Faculty of Medicine and Surgery of Florence as Pharmacology Instructor in the Integrated Course of General Pathology in CDL Physiotherapy, Principal of Basic Neuropsychology in the School of Specialization in Psychiatry, co- holder of Basic Neuropsychology in Neurology, Neurophysiopathology and Pharmacology Specialization Schools. He is the scientific tutor of PhD School of Pharmacology and Toxicology at the University of Florence. co-holder of basic Neuropsychology teaching in Neurology, Neurophysiopathology and Pharmacology Specialization Schools. He is the scientific tutor of PhD School of Pharmacology and Toxicology at the University of Florence. co-holder of basic Neuropsychology teaching in Neurology, Neurophysiopathology and Pharmacology Specialization Schools. He is the scientific tutor of PhD School of Pharmacology and Toxicology at the University of Florence. She studies neurodegenerative diseases with immunohistochemical, biochemical, behavioral, and proteomic techniques. Studies of neurodegeneration, brain inflammatory processes and oxidative damage in Alzheimer's disease in in vivo animal models, including injected rats intracerebro with the amyloid peptide Aß (1-42) and / or fragments thereof, with non-bacterial bacterial proteins and in transgenic mice with human mutation of the amino acid precursor protein. These models studied the effect of anti-inflammatory, neuroprotective drugs and drugs that correct cholinergic hypofunction (cholinergic inhibitors). The main issues addressed in recent years are: 1) Study of the neurotoxic effects of intracerebral injection of amyloid peptide Aß (1-42) and quitqualic acid excitotoxin and the anti-inflammatory and neuroprotective action of the chronic administration of rofecoxib, flurbiprofen and its two NO derivatives. 2) Study of the neurotoxicity of pre-fibrillar aggregates of non-disease-related proteins. In collaboration with the Biochemistry Research Group of Florence, led by Prof. Stefani, has shown that pre-fibrillar aggregates of non-associated diseases are in vivo neurotoxic supporting the concept that under any particular conditions any protein can misfold in a state capable of compromising cell viability. of flurbiprofen and its two NO derivatives. 2) Study of the neurotoxicity of pre-fibrillar aggregates of non-disease-related proteins. In collaboration with the Biochemistry Research Group of Florence, led by Prof. Stefani, has shown that pre-fibrillar aggregates of non-associated diseases are in vivo neurotoxic supporting the concept that under any particular conditions any protein can misfold in a state capable of compromising cell viability. of flurbiprofen and its two NO derivatives. 2) Study of the neurotoxicity of pre-fibrillar aggregates of non-disease-related proteins. In collaboration with the Biochemistry Research Group of Florence, led by Prof. Stefani, has shown that pre-fibrillar aggregates of non-associated diseases are in vivo neurotoxic supporting the concept that under any particular conditions any protein can misfold in a state capable of compromising cell viability. 3) Role of oxidative stress in the pathogenetic cascade of amyloid protein. In collaboration with Prof. Butterfield of the University of Kentucky, proteomic techniques have been identified with oxidized proteins in different brain areas (bark, hippocampus and Meynert nucleus). 4) Study in TgCRND8 transgenic mouse with APP human mutation of neuroinfiammation, histopathological alterations and central cholinergic mechanisms and study of new therapeutic approaches in Alzheimer's disease. He collaborates with important Italian and foreign laboratories as evidenced by work written in collaboration with researchers from other laboratories. This research led the Prof. to join a European research project that sees participation, as well as Italy, Germany, Denmark, Holland, England and Finland. The Professor is one of the eight partners of a 6FP IP financed by the European Community under "Novel therapeutic substances for neurodegenerative diseases in CNS and PNS". The title of the funded project is 5 years of "Design of small molecule therapies for the treatment of Alzheimer's disease based on the discovery of innovative drug targets". In addition to studies on Alzheimer's disease, Prof. studied, in collaboration with Dr. Maria Grazia Spillantini of the University of Cambridge, UK, the analogies between the neuroinfiammation of patients with taupats and transgenic mice of the mutated human form of tau P301S. He also studies neurodegeneration in an experimental model of multiple sclerosis. For this purpose, Prof.ssa introduced in his laboratory the experimental model of multiple sclerosis (EAE) in C57B16 / j mice induced by myogeneic protein MOG, peptide 35-55, and is studying the axonopathy associated with inflammatory cascade and l 'effect of drugs such as minocycline and statin. He also studies neurodegeneration in an experimental model of multiple sclerosis. For this purpose, Prof.ssa introduced in his laboratory the experimental model of multiple sclerosis (EAE) in C57B16 / j mice induced by myogeneic protein MOG, peptide 35-55, and is studying the axonopathy associated with inflammatory cascade and l 'effect of drugs such as minocycline and statin. He also studies neurodegeneration in an experimental model of multiple sclerosis. For this purpose, Prof.ssa introduced in his laboratory the experimental model of multiple sclerosis (EAE) in C57B16 / j mice induced by myogeneic protein MOG, peptide 35-55, and is studying the axonopathy associated with inflammatory cascade and l 'effect of drugs such as minocycline and statin.

Research Interest

Neurology