Persio Dello Sbarba

Biography

born in Pisa on June 20, 1953; 1979 degree in Medicine and Surgery at the University of Florence; 1982 Diploma in Specialization in Clinical Immunology and Allergology at the University of Florence; 1988 Ph.D. degree in Experimental Pathology; 1983-1990 Assignee of the National Research Council at the Institute of General Pathology of the University of Florence; 1987-1990 Research Associate in the Department of Microbiology and Immunology, then Department of Developmental Biology and Cancer at the Albert Einstein College of Medicine in New York; 1990-2001 Technical Officer at the Institute of General Pathology, then Department of Pathology and Experimental Oncology, University of Florence; 1995 Guest Researcher at the Institute for Microbiology and Genetics, Universität Wien; 2001- Associate Professor of General Pathology at the Faculty of Medicine and Surgery of the University of Florence. Member of the following scientific societies: International Society for Experimental Hematology; British Society for Immunology; Italian Society of Experimental Hematology; Italian Society of Immunology; Italian Society of Pathology. scientific activity Ultimately, Prof. Dello Sbarba has been researching both cellular and molecular levels in the following fields: (A) the role of hypoxia in controlling the survival and proliferation of normal and neoplastic haematopoietic stem cells and progenitors; (B) control of survival and proliferation of stem cells and progenitor leukemia; (C) control of survival, proliferation and motility of macrophages; (D) modulation of macrophage activation and response to MCSF in activated macrophages. In relation to the above, Prof. Dello Sbarba is or has been the scientific director of the following major research projects: 1) "Inhibition of BCR / Abl expression and induction of alternative antiapoptotic mechanisms in hypoxia-adapted / Imatinib-insensitive CML stem cells", funded for 2008-2009 by the Toscano Tumori Institute. 2) "Role of Hypoxia in the Selection and Maintenance of Normal and Neoplastic Haematopoietic Stem Cells", funded for 2003-2005 by the Higher Institute of Health, under the National Stem Cell Program (Topic Area 1A - CS64 Convention); 3) "Role of microenvironment and epigenetic events in the regulation of leukemia stem cell compartment" funded for 2008-2010 by the Italian Federation for Cancer Research (FIRC). 4) "The role of microenvironment and epigenetic events in the regulation of the leukemic stem cell compartment" funded for 2007-2008 by the FIRC. 5) "Characterization of BCR-Abl-Negative Stimulants and Itaminib Resistant of Chronic Myeloid Leukemia and Assay of Their Interferon- Sensitivity" Funded for 2008 by the Italian Association Leucemie (AIL). 6) "Hypoxia modulation of BCR / Abl expression and other phenotypic characters in chronic myeloid leukemia cells" funded by the ALA for 2007. 7) "Role of hypoxia in the control of cell growth in myeloid leukemia", funded for 2003-2004 by the ANA. 8) "Role of hypoxia and fossil genes in the control of cell growth in chronic myeloid leukemia", funded for 2002-2003 by the FA.

Research Interest

General pathology