Koyama Hiroko
Assistant Professor
Department of Chemistry and Biomolecular Science
Gifu University
Japan
Biography
Koyama Hiroko is currently working in Gifu University,Japan. Her research work is on Positron emission tomography (PET) is a noninvasive molecular imaging technique for monitoring drug (or drug candidate) behavior and its localization in the living system. Especially, it is a superior method to develop study of brain. We have proceeded “the development of rapid C-methylations useful for PET tracers synthesis labeled by short-lived positron-emitting radionuclides 11C with a half-life of 20.4 min” under the leadership of Prof. Suzuki. As main results, we have established rapid C-[11C]methylaiton into a hetero-aromatic ring which appear in major drugs and the rapid cross-coupling reaction between two sp3-hybridized carbons. These reactions proceed in only five minutes. We have completed to realize our-objected four types of rapid C-[11C]methylations generally applicable to the 11C-labeling of almost any organic frameworks. Recently, based on these methods, we successfully synthesized a high functional PET probes toward the drug development and diagnosis of brain functional disorder (such as Alzheimer’s disease) and brain tumor (such as drug resistance cancer).
Research Interest
His research interest is on 11C and 18F labeling method, high-functional PET probe, in vivo molecular imaging
