Makoto Arita
Team Leader
Laboratory for Metabolomics
The Institute of Physical and Chemical Research (RIKEN)
Japan
Biography
Our research is aimed at elucidating structure and function of endogenous lipid mediators that regulate inflammation and tissue homeostasis. LC-MS/MS-based lipidomics concerns the simultaneous and quantitative analysis to find a potential link between lipid metabolism and biological phenotype. Our current research is focused on understanding ω3 PUFA’s function using genetic and lipidomic approaches, and has identified novel metabolic pathway and bioactive metabolites that may link to ω3 PUFA’s anti-inflammatory actions. These endogenous mediators with potent anti-inflammatory property could lead to the development of novel therapeutics for disease when sustained inflammation is suspected as key components of pathogenesis. Also we put a lot of efforts into development and application of advanced LC-MS/MS-based lipidomics system to discover novel bioactive metabolites.
Research Interest
Biology & Biochemistry
Publications
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Kubota T, Arita M, Isobe Y, Iwamoto R, Goto T, Yoshioka T, Urabe D, Inoue M, Arai H.: “Eicosapentaenoic acid is converted via omega-3 epoxygenation to anti-inflammatory metabolite 12-hydroxy-17,18-epoxyeicosatetraenoic acid.†FASEB J 28, 586-593 (2014)
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Tani Y, Isobe Y, Imoto Y, Segi-Nishida E, Sugimoto Y, Arai H, Arita M.: “Eosinophils control the resolution of inflammation and draining lymph node hypertrophy through the proresolving mediators and CXCL13 pathway in mice.†FASEB J 28, 4036-4043 (2014)
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Endo J, Sano M, Isobe Y, Fukuda K, Kang JX, Arai H, Arita M.: “18-HEPE, an n-3 fatty acid metabolite released by macrophages, prevents pressure overload-induced maladaptive cardiac remodeling.†J Exp Med 211, 1673-1687 (2014)
