Kazuhiko Igarashhi
Professor
Department of Biochemistry
Tohoku University
Japan
Biography
Dr. Kazuhiko Igarashhi, is a Professor of Biochemistry, at Tohoku University School of medicine. He is M.D. and Ph.D. His research themes are Regulation of the development and differentiation of immune cells by transcription factors and epigenome, and its pathological implications, Regulation of erythropoiesis and immune cells by the prosthetic group heme, and its pathological implications, Nuclear proteins network for histone methylation, and its pathological implications. Research Keywords for him are transcription factors, chromatin, epigenome, B lymphoid cell, macrophage, erythroid cell,.
Research Interest
mass spectrometry analysis, next generation sequencing, bioinformatics, mouse, molecular biology
Publications
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Sun, J., Hoshino, H., Takaku, K., Nakajima, O., Muto, A., Suzuki, H., ... & Taketo, M. M. (2002). Hemoprotein Bach1 regulates enhancer availability of heme oxygenaseâ€1 gene. The EMBO journal, 21(19), 5216-5224.
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Oyake, T., Itoh, K., Motohashi, H., Hayashi, N., Hoshino, H., Nishizawa, M., ... & Igarashi, K. (1996). Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site. Molecular and cellular biology, 16(11), 6083-6095.
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Ross, W., Gosink, K. K., Salomon, J., Igarashi, K., Zou, C., Ishihama, A., ... & Gourse, R. L. (1993). A third recogni-tion element in bacterial promoters: DNA binding by the ot subunit of RNA polymerase. Science, 262, 1407-1413.
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Kobayashi, A., Kang, M. I., Okawa, H., Ohtsuji, M., Zenke, Y., Chiba, T., ... & Yamamoto, M. (2004). Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Molecular and cellular biology, 24(16), 7130-7139.
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Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999). Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes & development, 13(1), 76-86.
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Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., ... & Yamamoto, M. (1997). An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochemical and biophysical research communications, 236(2), 313-322.
