Frank Holstege
Research
Utrecht University
Netherlands
Biography
Frank Holstege (born 1966 in Sittard, NL, PhD 1996 from Utrecht University, NL) has pioneered Genomics and Systems Biology analyses of gene expression, first as a post-doc at the Whitehead Institute for Biomedical Research/MIT, and since 2000 as a group leader at the Department for Molecular Cancer Research of the University Medical Center Utrecht. His group works on developing Genome Control Maps, uses a unique robotic system for gene expression-profiling to uncover novel regulatory mechanisms and has patented diagnositic signatures for disease prognosis.
Research Interest
gene expression profiling
Publications
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T.L. Lenstra, J.J. Benschop, T. Kim, J.M. Schulze, N.A.C.H. Brabers, T. Margaritis, L.A.L. van de Pasch, S.A.A.C. van Heesch, M.O. Brok, M.J.A. Groot Koerkamp, C.Ko, D. van Leenen, K. Sameith, S.R. van Hooff, P. Lijnzaad, P. Kemmeren, T. Hentrich, M.S. Kobor, S. Buratowski, F.C.P.Holstege. The specificity and topology of chromatin interaction pathways in yeast. Molecular Cell 2011 (accepted)
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A. Brazma, P. Hingamp, J. Quackenbush, G. Sherlock, P. Spellman, C. Stoeckert, J. Aach, W. Ansorge, C. Ball, H. Causton, F. Holstege, et al. Minimum information about a microarray experiment (miame) - toward standards for microarray data. Nature Genetics 2001, 29(4): 365-71.
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A. Margaritis, F. Holstege. RNA polymerase II poised on the genome – a pause for thought. Cell 2008, 133, 581-4.
