Xiongbin Lu, Ph.d.

Biography

I have been enjoying the dynamic and challenging nature of cancer research, which drives me to do something that is new and important at each stage of my academic career. I was trained as a virologist with emphasis on viral entry and infectivity (Lu X et al., Virology 2000; Lu X et al., Journal of Virology 2001). After my first postdoctoral training at NIAID/NIH, I decided to take a challenge to study cancer biology in Dr. Donehower’s laboratory where the first p53 knockout 

Research Interest

 I was fascinated by the complex function and regulation of the p53 tumor suppressor. My initial work contributed to an important Nature research article concerning the role of p53 on organismal aging (Tyner S et al., Nature 2001), which was reported by a number of mainstream media such as BBC, Washington Post, and New York Times. Since then, I have been looking into molecular mechanisms for the induction and hemostatic regulation of p53. My early work determined that Wip1 phosphatase is a master inhibitor in the ATM-p53 signaling pathway.