Lee, Caroline
Associate Professor
Cancer & Stem Cell Biology
Duke-NUS Graduate Medical School
Singapore
Biography
Caroline Lee graduated with PhD from Baylor College of Medicine and did her post-doctoral training at the National Cancer Institute, National Institutes of Health. She currently also holds joint appointment as Principal Investigator at the National Cancer Centre as well as an Associate Professor at the Cancer and Stem Cell Biology Program at Duke-NUS Graduate Medical School. She has ~100 peer reviewed publications and research focuses on the functional genomics of hepatocellular carcinoma (HCC) and pharmacogenetics.
Research Interest
Our laboratory focus on utilizing computational, genetical, molecular and cellular biological tools to elucidate the molecular and cellular pathways that may lead to the carcinogenesis process as well as to understand genetic variations that may account for differences in our response to drugs as well as susceptibility to complex diseases including cancer.
Publications
-
Yan Xiang, Zachary E. Stine, Jinsong Xi, Yunqi Lu, Roddy S. O’Connor, Brian J. Altman, Annie L. Hsieh, Arvin M. Gouw, Ajit G. Thomas, Ping Gao, Linchong Sun, Libing Song, Benedict Yan, Barbara S. Slusher, Jingli Zhuo, London L. Ooi, Caroline G.L. Lee, Anthony Mancuso, Andrew S. McCallion, Anne Le, Michael C. Milone, Stephen Rayport, Dean W. Felsher, Chi V. Dang. On-target inhibition of glutaminase diminishes cell autonomous tumorigenesis. Journal of Clinical Investigation J Clin Invest. 2015. 125(6): 2293-2306
-
Cheryl CHAN, Thomas THURNHERR, Jingbo WANG, Xavier GALLART-PALAU, Siu Kwan SZE, Steve ROZEN and Caroline G. LEE. Global re-wiring of p53 transcription regulation by the hepatitis B virus X protein. Molecular Oncology 2016 (in press) ( doi: 10.1016/j.molonc.2016.05.006.
