Sylvie Alonso
Associate Professor
Department of Microbiology and Immunology
Duke-NUS Graduate Medical School
Singapore
Biography
She is an Associate Professor at Department of Microbiology and Immunology and currently handeling the projects like Persistence mechanisms of M. tuberculosis ,Dengue pathogenesis and development of an animal model of severe dengue,Enterovirus 71 neuropathogenesis Subunit vaccine development.
Research Interest
To Explore host-pathogen interactions in order to better understand the role of bacterial/viral virulence factors in pathogenicity and in the induction of host (immune) responses, Mechanisms involved in i) persistence of Mycobacterium tuberculosis, ii) neurovirulence/neurotropism of Enterovirus 71, and iii) Dengue disease severity. In addition to in vitro cell culture systems, we have developed and established mouse models of infection.
Publications
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Ang ML, Zainul Rahim SZ, Guanghou S, Dianišková P, Madacki J, Lin W, Koh V, Martinez Gomez JM, Sudarkodi S, Bendt A, Wenk M, Mikušová K, Korduláková J, Pethe K, Alonso S (2014) An ethA/R-deficient Mycobacterium bovis BCG mutant displays increased adherence to mammalian cells and greater persistence in vivo which correlate with altered mycolic acids composition. Infection and Immunity, 82(5): 1850-1959.
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Lee PX, Ong LC, Libau EA, Alonso S (2016). Relative contribution of dengue IgG antibodies acquired during gestation or breastfeeding in mediating dengue disease enhancement and protection in type I interferon receptor-deficient mice. PLOSntd.10(6):e0004805.
