Amir Hakim
Researcher
Faculty of Medicine
National Heart Lung Institute
United Kingdom
Biography
Amir Hakim is a Fellow within the Department of Medicine, Imperial College London. He is responsible for teaching and supervision of research projects on Allergy and Clinical Research postgraduate degrees. He is currently the module lead for Research and Professional skills within the department of Medicine and the National Heart & Lung Institute (NHLI). He also serves as a Postgraduate Tutor for the Department of Medicine. Amir is currently investigating whether metabolic products of high fibre diet, short chain fatty acids, can dampen airway inflammation and improve lung function. Amir completed his PhD within the NHLI, where he focused on novel mechanisms of corticosteroid resistance in COPD patients. His work received an International Scholarship Award from the American Thoracic Society. Before embarking on a PhD programme at Imperial College, Amir was awarded a scholarship to read Pharmacology at Masters Level at Oxford University. During his Masters, he worked on ‘Investigating novel anti-tubercular agents’. He examined the effects of various inhibitors of N-Acetyltransferase, an enzyme essential for Mycobacterium Tuberculosis cell wall synthesis, on bacterial cell growth and survival.
Research Interest
Genomic Medicine
Publications
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Haque R, Hakim A, Moodley T, et al., 2013, Inhaled long-acting beta(2) agonists enhance glucocorticoid receptor nuclear translocation and efficacy in sputum macrophages in COPD, Journal of Allergy and Clinical Immunology, Vol:132, ISSN:0091-6749, Pages:1166-1173
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Hakim A, Barnes PJ, Adcock IM, et al., 2013, Importin-7 mediates glucocorticoid receptor nuclear import and is impaired by oxidative stress, leading to glucocorticoid insensitivity, Faseb Journal, Vol:27, ISSN:0892-6638, Pages:4510-4519