Dr Jamel Mankouri
Royal Society University Research Fellow / Univers
School of Molecular and Cellular Biology
University of Leeds
United Kingdom
Biography
Post-doctoral researcher with Prof Mark Harris in the School of Molecular and Cellular Biology, University of Leeds (2006 - 2009); Post-doctoral Researcher with Prof Mark Harris and Dr Stephen Griffin (2009-2011) in the School of Molecular and Cellular Biology, University of Leeds. Royal Society University Research Fellow (2011-present).
Research Interest
Investigating host cell ion channel function as a novel target during virus infection Newly identified factors shown to be important in leading virus entry, survival and release are cellular ion channels, proteins that act as a pore in the membranes of all cells within the body, permitting the selective passage of ions (such as potassium ions, sodium ions, and calcium ions). Through controlling ion passage, these channels serve many critically important cellular functions including chemical signaling, the regulation of pH, and the regulation of cell volume. Malfunction of ion channels can cause diseases in many tissues.
Publications
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Hover S, Foster B, Barr JN, Mankouri J, (2017). Viral dependence on cellular ion channels - an emerging anti-viral target? J Gen Virol 98: 345-351.
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Mankouri J, Taneja TK, Smith AJ, Ponnambalam S, Sivaprasadarao A, (2006). Kir6.2 mutations causing neonatal diabetes prevent endocytosis of ATP-sensitive potassium channels EMBO J 25 4142-4151.
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Mankouri J, Dallas ML, Hughes ME, Griffin SDC, Macdonald A, et al., (2009). Suppression of a pro-apoptotic K+ channel as a mechanism for hepatitis C virus persistence. Proc Natl Acad Sci U S A 106: 15903-15908.
