Joseph Blattman
Assistant Professor
Infectious Diseases and Vaccinology, Center for (IDV)
Arizona State University
United States of America
Biography
Joseph Blattman is an immunologist who studies how the immune system responds to vaccination and viral infection. Focusing on T cell immune responses, he is investigating how vaccines affect the balance between immunologic protection from infection or tumor growth, and disease enhancement due to immunopathology. Blattman and his research team use quantitative mathematical models to describe the kinetics of infection and immune responses in the body. This allows them to predict which aspects of a T cell response protect the body and which contribute to disease progression. The team tests show T cell responses affect susceptibility to infection, disease severity after infection and subsequent pathogen transmission.Their work is being used to develop safer and more effective vaccines for humans.
Research Interest
T cell receptor diversity vs. efficacy,T cell response pathology vs. protection ,Linking immunologic and epidemiologic measures of vaccine efficacy,Immunotherapy of Persistent Viral Infection and Metastatic Cancer
Publications
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Lettieri, C. K., Appel, N., Labban, N., Lussier, D. M., Blattman, J. N., & Hingorani, P. (2016). Progress and opportunities for immune therapeutics in osteosarcoma. Immunotherapy, 8(10), 1233-1244. DOI: 10.2217/imt-2016-0048
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Lussier, D. M., Woolf, E. C., Johnson, J. L., Brooks, K. S., Blattman, J. N., & Scheck, A. C. (2016). Enhanced immunity in a mouse model of malignant glioma is mediated by a therapeutic ketogenic diet. BMC Cancer, 16(1), [310]. DOI: 10.1186/s12885-016-2337-7
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Meador, L. R., Kessans, S. A., Kilbourne, J., Kibler, K. V., Pantaleo, G., Roderiguez, M. E., ... Mor, T. S. (2017). A heterologous prime-boosting strategy with replicating Vaccinia virus vectors and plant-produced HIV-1 Gag/dgp41 virus-like particles. Virology, 507, 242-256. DOI: 10.1016/j.virol.2017.04.008
