Kevin Gardner
Director of the Structural Biology Initiative of t
Chemistry and Biochemistry
City University of New York
United States of America
Biography
Kevin H. Gardner received his B.S. in Biochemistry from UC Davis before obtaining his Ph.D. degree in Molecular Biophysics & Biochemistry from Yale University for his research with Dr. Joseph Coleman on the development of new NMR methods to study metalloprotein structure and dynamics. Continuing his training in structural biology, he did a postdoctoral fellowship with Dr. Lewis Kay at the University of Toronto, developing novel isotopic labeling and other methods for the study of large proteins and their complexes with solution NMR. Dr. Gardner began his independent academic career at the UT Southwestern Medical Center in Dallas, where he established a structural biology research group within the Departments of Biophysics and Biochemistry, exploring regulatory mechanisms of several classes of sensory proteins and discovering ways which these may be controlled by natural or artificial stimuli in the process.
Research Interest
Environmentally-regulated protein/protein interactions
Publications
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Scheuermann, T.H., Li, Q., Ma, H.-W., Key, J., Zhang, L., Chen, R., Garcia, J.A., Naidoo, J., Longgood, J., Frantz, D.E., Tambar, U.K., Gardner, K.H.†and Bruick, R.K.†(2013) Allosteric inhibition of Hypoxia Inducible Factor 2 with small molecules. Nat. Chem. Biol., 9: 271-276
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Correa, F., Ko, W.-H., Ocasio, V., Bogomolni, R.A. and Gardner, K.H. (2013) Blue light regulated two-component systems: Enzymatic and functional analysis of light-oxygen-voltage (LOV)-histidine kinases and downstream response regulators. Biochemistry, 52: 4656-4666
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Motta-Mena, L.B., Reade, A., Mallory, M.J., Glantz, S., Weiner, O.D., Lynch, K.W. and Gardner, K.H. (2014) An optogenetic gene expression system with rapid activation and deactivation kinetics. Nature Chem. Biol., 10: 196-202.
