Jin Fan
ASSISTANT PROFESSOR
Neuroscience and Psychiatry
Icahn School of Medicine at Mount Sinai
United States of America
Biography
Through independent research and collaborations, Dr. Fan has conducted a series of studies on attentional networks. An Attention Network Test (ANT) was developed to provide a behavioral measure of the efficiency of the three attentional networks. Behavioral, developmental, patient, functional magnetic resonance imaging (fMRI), event related potentials (ERP), and genetics studies were conducted to investigate the anatomy, circuitry, pathology, and development of attentional networks. It was shown that the executive control network is highly heritable. Performance in resolving conflict relates to two dopamine genes. Subsequent imaging-genetic studies on a smaller genetically defined cohort showed that specific variants of the MAOA and DRD4 genes contribute to individual differences in functional activation of the anterior cingulate gyrus and other brain areas. The computational modeling offered the real possibility of linking and cross-validating findings from different studies and provided comprehensive predictions for the interactions among these networks.
Research Interest
Neuroscience and Psychiatry
Publications
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Fan J, Wu Y, Fossella J, Posner MI (2001) Assessing the heritability of attentional networks. BMC Neuroscience 2: 14.
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Fan J, Mccandliss BD, Sommer T, Raz A, Posner MI (2002) Testing the efficiency and independence of attentional networks. J Cogn Neurosci 14: 340-347.
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Fan J, Fossella J, Sommer T, Wu Y, Posner MI (2003) Mapping the genetic variation of executive attention onto brain activity. Proc Natl Acad Sci USA 100: 7406-7411.
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Fan J, Flombaum JI, Mccandliss BD, Thomas KM, Posner MI (2003) Cognitive and brain consequences of conflict. Neuroimage 18: 42-57.
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Fan J, Mccandliss BD, Fossella J, Flombaum JI, Posner MI (2005) The activation of attentional networks. Neuroimage 26: 471-479.
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Fan J, Kolster R, Ghajar J, Suh M, Knight RT, etal (2007) Response anticipation and response conflict: An event-related potential and functional magnetic resonance imaging study. J Neurosci 27: 2272-2282.
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Fan J, Byrne J, Worden MS, Guise KG, McCandliss BD, etal (2007) The relation of brain oscillations to attentional networks. J Neurosci 27: 6197-6206.
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Fan J, Hof PR, Guise K, Fossella JA, Posner MI (2008) The functional integration of the anterior cingulate cortex during conflict processing. Cerebral Cortex 18: 796-805
