Linda Lowe-krentz
Professor
Bioengineering
Lehigh University
United States of America
Biography
Linda Lowe-Krentz is a professor in the department of biological sciences in the College of Arts and Sciences at Lehigh University. Dr. Lowe-Krentz is also a member of the bioengineering advisory program and the health professions advisory committee at Lehigh. Her research in vascular cell signal transduction and stress is supported by the NIH and currently also through an interdisciplinary award to Mechanical/Bioengineering Professor Yaling Liu of Lehigh University. She teaches Biochemistry courses, has taught Anatomy and Physiology and often teaches a non-majors Health-focused first year seminar.
Research Interest
Biochemistry
Publications
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Mengistu, M., Slee, J.B., and Lowe-Krentz, L.J. 2012. Ch V. Stressed out and actin up: stress-activated protein kinase regulation of actin remodeling directs endothelial cell morphology and migration. In: Actin: Structure, Functions and Disease. Eds. VA Consuelas, et al., Hauppauge, NY: Nova Sciences Publishers, Inc. ISBN: 978-1-62100-191-1. Pp 177-205.
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Slee, J.B. and Lowe-Krentz, L.J. 2013. Actin realignment and cofilin regulation are essential for barrier integrity during shear stress. J. Cellular Biochemistry. 114:782-795. Published on-line in Oct 2012 as: DOI: 10.1002/jcb.24416.
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Gilotti, AC, Nimlamool, W, Pugh, R, Slee JB, Barthol TC, Miller EA, and Lowe-Krentz, LJ. 2014. Heparin responses in vascular smooth muscle cells involve cGMP dependent protein kinase. J Cell. Physiol. 229: 2142-2152.
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Farwell, S.L.N., Kanyi, D., Hamel, M., Slee, J.B., Miller, E.A., Cipolle, M.D., Lowe-Krentz, L.J. 2016. Heparin decreases in TNFα-induced endothelial stress responses require transmembrane protein 184A and induction of dual specificity phosphatase-1. J. Biol. Chem. 2016 Jan 14 pii: jbc.M115.681288.
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Pugh, R., Slee, J.B., Farwell, S.L.N., Li, Y., Barthol, T., Patton, W.A. and Lowe-Krentz, L.J. 2016. Transmembrane protein 184A is a receptor required for vascular smooth muscle cell responses to heparin. J. Biol. Chem. 2016 Jan 14pii: jbc.M115.681122.
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Thomas, A., Ou-Yang, H.D., Lowe-Krentz, L., Muzykantov, V.R. and Liu, Y. 2016. Biomimetic channel modeling local vascular dynamics of pro-inflammatory endothelial changes. Biomicrofluidics. 10, 014101 (January, 2016) DOI: 10.1063/1.4936672
