Ed Harlow
Scientist
Ludwig Center at Harvard
Ludwig Institute for Cancer Research
United States of America
Biography
My career has focused on cancer biology, most importantly the control of cell division and the molecular and cellular changes that initiate and maintain the cancerous transformation. I served at Cold Spring Harbor Laboratory from 1982 to 1990, later serving as Scientific Director for the Massachusetts General Hospital Cancer Center and as Associate Director for Science Policy at the National Cancer Institute, where I helped direct U.S. cancer research planning. I have also served as Professor and Chair of the Department of Biological Chemistry and Molecular Pharmacology at the Harvard Medical School and Associate Director of the Dana-Farber/Harvard Cancer Center. Most recently, in addition to my work at Harvard Medical School as one of the recipients of the Virginia and Daniel K. Ludwig Professor Chairs at Harvard Medical School, I serve as an advisor to Dr. Harold Varmus at the National Cancer Institute to help our country address many of the critical challenges and opportunities facing cancer research today.
Research Interest
Cancer biology, molecular pharmacology, cancer therapeutics
Publications
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Lee SB, Kim SH, Bell DW, Wahrer DC, Schiripo TA, Jorczak MM, Sgroi DC, Garber JE, Li FP, Nichols KE, Varley JM, Godwin AK, Shannon KM, Harlow E, Haber DA. “Destabilization of CHK2 by a missense mutation associated with Li-Fraumeni Syndrome.†Cancer Res. 2001 Nov 15;61(22):8062-7.
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Johnson BR, Nitta RT, Frock RL, Mounkes L, Barbie DA, Stewart CL, Harlow E, Kennedy BK. “A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation.†Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9677-82. Epub 2004 Jun 21.
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Pearlberg J, Degot S, Endege W, Park J, Davies J, Gelfand E, Sawyer J, Conery A, Doench J, Li W, Gonzalez L, Boyce FM, Brizuela L, Labaer J, Grueneberg D, Harlow E.“Screens using RNAi and cDNA expression as surrogates for genetics in mammalian tissue culture cells.Cold Spring Harb Symp Quant Biol. 2005;70:449-59.â€
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Bommi-Reddy A, Almeciga I, Sawyer J, Geisen C, Li W, Harlow E, Kaelin Jr. WG, and Grueneberg DA. "Kinase Requirements in Human Cells: III. Altered Kinase Requirements in VHL-/- Renal Carcinoma Cells Detected in a Pilot Synthetic Lethal Screen.†PNAS.2008 Oct 28;105(43):16484-9. Epub 2008 Oct 23.
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Grueneberg DA, Degot S, Pearlberg J, Li W, Davies JE, Baldwin A, Endege W, Doench J, Sawyer J, Hu Y, Boyce F, Xian J, Munger K, and Harlow E. "Kinase Requirements in Human Cells: I. Comparing Kinases Requirements Across Various Cell Types.†PNAS.2008 Oct 28;105(43):16472-7. Epub 2008 Oct 23.
