Mioara Larion
Investigator
Center for Cancer Research
National Cancer Institute
United States of America
Biography
Dr. Mioara Larion received her B.Sc. in Biochemistry from Cuza University, Lasi, Romania in 2002. She moved to Florida State University where she received a M.Sc. in Biophysics in 2005 working on saturation transfer electron paramagnetic resonance methods and their sensitivity to molecular motion upon increasing the field. In 2009, Dr. Larion received her Ph.D. in Biochemistry working on divergent evolution of function in bacterial kinases and the origin of kinetic cooperativity in human pancreatic glucokinase in the laboratory of Prof. Brian Miller. After obtaining her Ph.D in 2009, she was awarded the AHA postdoctoral fellowship to work with Prof. Rafael Brüschweiler on biophysical characterization of glucokinase and PHHI-like variants. Her work helped understand the mechanism of glucokinase’s activation for design of better anti-diabetic therapeutics. Her major interest is in metabolomics of brain tumors.
Research Interest
1) metabolomics, 2) nuclear magnetic resonance, 3) mass spectrometry, 4) hyperpolarized MRI
Publications
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Larion M, Hansen AL, Zhang F, Bruschweilerâ€Li L, Tugarinov V, Miller BG, Brüschweiler R. Kinetic cooperativity in human pancreatic glucokinase originates from millisecond dynamics of the small domain. Angewandte Chemie. 2015 Jul 6;127(28):8247-50.
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Whittington AC, Larion M, Bowler JM, Ramsey KM, Brüschweiler R, Miller BG. Dual allosteric activation mechanisms in monomeric human glucokinase. Proceedings of the National Academy of Sciences. 2015 Sep 15;112(37):11553-8.
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Larion M, Salinas RK, Bruschweiler-Li L, Miller BG, Brüschweiler R. Order–disorder transitions govern kinetic cooperativity and allostery of monomeric human glucokinase. PLoS biology. 2012 Dec 18;10(12):e1001452.
