Christopher J. Westlake
Laboratory of Cell and Developmental Signaling
The Center for Cancer Research
United States of America
Biography
In 2004, Dr. Westlake obtained his Ph.D. in Biochemistry under the supervision of Dr. Roger Deeley at Queen's University in Canada. While there, he investigated the structure/function and trafficking of multidrug resistance proteins (MRP) that are important in resistance to chemotherapeutics. He then joined Dr. Richard Scheller at Genentech as a postdoctoral fellow investigating membrane trafficking regulation by the Rab small GTPase family. In 2011, Dr. Westlake joined the Laboratory of Cell and Developmental Signaling at the Center for Cancer Research where he studies membrane trafficking pathways important in ciliopathy, diseases linked to primary cilia dysfunction, and cancer.
Research Interest
Biomedical Engineering and Biophysics, Cancer Biology, Cell Biology, Developmental Biology
Publications
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Greer YE, Westlake CJ, Gao B, Bharti K, Shiba Y, et al. (2014) Casein kinase 1δ functions at the centrosome and Golgi to promote ciliogenesis. Mol. Biol. Cell. 25: 1629-40.
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Asante D, Maccarthy-Morrogh L, Townley AK, Weiss MA, Katayama K, et al. (2013) A role for the Golgi matrix protein giantin in ciliogenesis through control of the localization of dynein-2. J. Cell. Sci. 126: 5189-97.
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Westlake CJ, Baye LM, Nachury MV, Wright KJ, Ervin KE, et al. (2011) Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome. Proc. Natl. Acad. Sci. U.S.A. 108: 2759-64.
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Westlake CJ, Junutula JR, Simon GC, Pilli M, Prekeris R, et al. (2007) Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene. Proc. Natl. Acad. Sci. U.S.A. 104: 1236-41.
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Lu Q, Insinna C, Ott C, Stauffer J, Pintado PA, et al. (2015) Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation. Nat. Cell Biol. 17: 228-40.
