Philipp Oberdoerffer
Laboratory of Receptor Biology and Gene Expression
The Center for Cancer Research
United States of America
Biography
In 2004, Dr. Oberdoerffer obtained his Ph.D. in Genetics and Immunology under the supervision of Dr. Klaus Rajewsky at the University of Cologne, Germany. He then joined Dr. David Sinclair's group at Harvard Medical School, first as a National Space Biomedical Research Institute (NSBRI) Investigator, and later as a Leukemia and Lymphoma Society Special Fellow. In 2009, he joined the Mouse Cancer Genetics Program at the Center for Cancer Research, NCI where he studies the molecular link between DNA damage, chromatin and aging. In 2013, Dr. Oberdoerffer joined the Laboratory for Receptor Biology and Gene Expression at NCI.
Research Interest
Cancer Biology, Chromosome Biology, Genetics and Genomics, Molecular Biology and Biochemistry
Publications
-
Burgess RC, Misteli T, Oberdoerffer P (2012) DNA damage, chromatin, and transcription: the trinity of aging. Curr. Opin. Cell Biol. 24: 724-30.
-
Shi L, Oberdoerffer P (2012) Chromatin dynamics in DNA double-strand break repair. Biochim Biophys Acta. 1819: 811-9.
-
Singh SK, Williams CA, Klarmann K, Burkett SS, Keller JR, et al. (2013) Sirt1 ablation promotes stress-induced loss of epigenetic and genomic hematopoietic stem and progenitor cell maintenance. J. Exp. Med. 210: 987-1001.
-
Liu J, Kim J, Oberdoerffer P (2013) Metabolic modulation of chromatin: implications for DNA repair and genomic integrity. Front Genet. 4: 182.
-
Khurana S, Kruhlak M, Kim J, Tran AD, Liu J, et al. (2014) A macrohistone variant links dynamic chromatin compaction to BRCA1-dependent genome maintenance. Cell Rep. 8: 1049-62.
