Cynthia Czajkowski
Distinguished Professor
department of neuroscience
University of Wisconsin-Madison
United States of America
Biography
Professor Cynthia Czajkowski pursued her Ph.D. in year 1987 from State University of New York. Her Research Interests includes- Mechanisms underlying pentameric ligand gated ion channel function Professor Czajkowski also published many artcals such as- "structural link between the GABA receptor's agonist binding site and inner b-sheet governs channel activation and allosteric drug modulation". "Different residues in the GABA-A receptor benzodiazepine binding pocket mediate benzodiazepine efficacy and binding". "Packing of the extracellular domain hydrophobic core has evolved to facilitate pentameric ligand-gated ion channel function". "Allosteric modulators induce distinct movements at the GABA-binding site interface of the GABA-A receptor". "Disulfide trapping of the GABA-A receptor reveals the importance of the coupling interface in benzodiazepine action".
Research Interest
Mechanisms underlying pentameric ligand gated ion channel function
Publications
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Sancar F, Czajkowski C. Allosteric modulators induce distinct movements at the GABA-binding site interface of the GABA-A receptor. Neuropharmacology. 2011 Mar 31;60(2):520-8.
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Dellisanti CD, Hanson SM, Chen L, Czajkowski C. Packing of the extracellular domain hydrophobic core has evolved to facilitate pentameric ligand-gated ion channel function. Journal of Biological Chemistry. 2011 Feb 4;286(5):3658-70.
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Morlock EV, Czajkowski C. Different residues in the GABAA receptor benzodiazepine binding pocket mediate benzodiazepine efficacy and binding. Molecular pharmacology. 2011 Jul 1;80(1):14-22.
