Katrin Rittinger
chemistry
Francis Crick Institute
United Kingdom
Biography
Katrin Rittinger obtained a degree in chemistry from the University of Heidelberg, Germany. She then went on to do a PhD at the Max Planck Institute for Medical Research in Heidelberg in the group of Roger Goody, characterising the nucleotide and oligonucleotide-binding properties of HIV reverse transcriptase and the mechanism of action of non-nucleoside RT inhibitors. After a short postdoctoral period at the Max Planck Institute for Molecular Physiology in Dortmund, Germany, she came to the Medical Research Council National Institute for Medical Research (now part of the Francis Crick Institute) in 1996 for a second postdoc, working on the structural characterisation of 14-3-3/ligand complexes and the regulation of Rho family GTPases.
Research Interest
number of protein assemblies that regulate different aspects of signal transduction using biochemical and structural methods characterising the nucleotide and oligonucleotide-binding properties of HIV reverse transcriptase and the mechanism of action of non-nucleoside RT inhibitors.
Publications
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Stieglitz, B., Morris-Davies, A.C., Koliopoulos, M.G., Christodoulou, E., and Rittinger, K. (2012). LUBAC synthesizes linear ubiquitin chains via a thioester intermediate. EMBO Rep 13, 840-846.
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Stieglitz, B., Haire, L.F., Dikic, I., and Rittinger, K. (2012). Structural Analysis of SHARPIN, a Subunit of a Large Multi-protein E3 Ubiquitin Ligase, Reveals a Novel Dimerization Function for the Pleckstrin Homology Superfold. J Biol Chem 287, 20823-20829
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Stieglitz, B., Rana, R.R., Koliopoulos, M.G., Morris-Davies, A.C., Schaeffer, V., Christodoulou, E., Howell, S., Brown, N.R., Dikic, I., and Rittinger, K. (2013). Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP. Nature 503, 422-426.
