Ross Davenport
trauma and vascular
(Harvard Medical International Associated) Hygeia Hospital of Athens
Antarctica
Biography
My main research interest is in the global derangement of clotting which occurs after major trauma haemorrhage - Trauma Induced Coagulopathy (TIC) and the earlier endogenous process of Acute Traumatic Coaguloapthy (ATC). The majority of my PhD thesis was dedicated to the functional and biochemical characterization of the ATC using Rotational Thromboelastometry (ROTEM) and I further demonstrated the importance of the Protein C pathway in this endogenous coagulopathy. We have shown that ROTEM is able to diagnose ATC within 5 minutes and is a more sensitive marker of massive haemorrhage predication than conventional, laboratory clotting screens. In addition our work has identified activation of fibrinolysis in almost all severely injured patients and provides some mechanistic evidence for the large RCT evaluating tranexamic acid in trauma haemorrhage (CRASH-2).
Research Interest
My main research interest is in the global derangement of clotting which occurs after major trauma haemorrhage - Trauma Induced Coagulopathy (TIC) and the earlier endogenous process of Acute Traumatic Coaguloapthy (ATC). The majority of my PhD thesis was dedicated to the functional and biochemical characterization of the ATC using Rotational Thromboelastometry (ROTEM) and I further demonstrated the importance of the Protein C pathway in this endogenous coagulopathy. We have shown that ROTEM is able to diagnose ATC within 5 minutes and is a more sensitive marker of massive haemorrhage predication than conventional, laboratory clotting screens. In addition our work has identified activation of fibrinolysis in almost all severely injured patients and provides some mechanistic evidence for the large RCT evaluating tranexamic acid in trauma haemorrhage (CRASH-2).
