has been at the ETH Zurich since April 1, 1991. He is full professor of Pharmaceutical Chemistry. Born in Andernach/Rhein in Germany, he studied pharmacy at the University of Bonn. He earned his Ph.D in Bonn on structure activity relationships of desapurines. In 1983 he transferred to the University of Tübingen, where he completed habilitation in 1989 in pharmaceutical chemistry. During a stay in Berne, Switzerland, he studied new research methods in computer aided molecular design. The focus of his research work is the molecular interaction between drugs and its binding sites in vivo. He is particularly interested in the strong integration of computer aided modeling and relevant biochemical/biophysical experiments. Besides the research on molecular mechanism of "conventional" nucleoside therapeutics against virus infection and cancer, his special interest has shifted to immuno therapeutics. He is editor of the journals "QSAR" and "Pharmaceutica Acta Helvetiae", author and editor of diverse scientific books, vice president of the "Schweizerischen Gesellschaft der Pharmazeutischen Wissenschaften", member of the executive board "Schweizerischen Akademie der Technischen Wissenschaften", as well as a member of the board of man international scientific societies.
Pharmaceutical Chemistry, Molecular Biology, Biochemical studies