Dr Xiao-ming Gao

Biography

Dr Gao practiced for more than 12-years as a cardiac surgeon. He commenced his basic research career in 1999 and was granted the Degree of Doctor of Medicine by Monash University in 2003. His research has been focusing on ischemic heart disease, cardiac hypertrophy, cardiomyopathy and heart failure using various murine models with experimental-induced heart diseases or with genetic-manipulation induced cardiac phenotypes. Dr Gao has built up substantial research experience and expertise in the areas of hemodynamics, cardiac remodeling at molecular, structural and functional levels, aging, sex dimorphism in heart disease, mouse pathophysiology, myocardial ischemic injury, inflammation, fibrosis, cell death and extracellular matrix remodelling and myocardial protection. His research focusing on the role of MIF in ischemic heart disease has made an important finding on a novel biomarker for early diagnosis of acute coronary artery syndrome and infarct size prediction with potential significances in clinical practice, which leads to an International Patent (PCT/AU2011/001027). Dr Gao has published 90 peer-reviewed research works since 1998, including 4 invited reviews and 2 book chapters. He is the First/co-first author, or corresponding author in 28 papers. The total citation of his works is over 2700 times, 6 papers are over 100 times and 15 are over 50 times.

Research Interest

The establishment and optimisation of different mouse models of heart diseases and a range of methodologies for in vivo detection of murine cardiac phenotypes such as hemodynamic, cardiac structural and functional remodelling and microvascular damage. Success in these areas has placed his laboratory at a leading position in Australia, The adrenergic mechanism in the development of heart failure in response to ischemic injury and pressure overload (indicated by 19 publications).