Dr Yung-chih (ben) Chen
Postdoctoral Fellow
Atherothrombosis and Vascular Biology
Baker Heart and Diabetes Institute
Australia
Biography
He graduated in 2011 from Monash University. During his PhD, he developed a new mouse model of atherosclerotic plaque instability that mimics human pathology most closely. This model has been published in the prestigious journal Circulation Research and has been rated the top 10 most downloaded article of the year. He also identified a list of new micro RNAs that are associated with plaque rupture. The other aspect of his research was establishing a non-invasive urine test, which would enable diagnosis of coronary artery disease with high sensitivity and specificity. This work has been published in two papers on human coronary artery disease (Journal of Proteome Research) as well as a paper using a mouse atherosclerosis ApoE-/- model (Molecular & Cellular Proteomics). He have presented my research data in over 12 national and international conferences. In summary, he have also won 6 travel awards, one student best Poster, one student best Oral, and a Young Investigator Award at the Australia Atherosclerosis Society meeting at 2013.
Research Interest
Atherothrombosis and unstable atherosclerotic plaque,Urine proteomic, Micro-RNA for anti-atherosclerotic therapy.
Publications
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Dr Yung-Chih Chen,Coinhibitory suppression of T cell activation by CD40 protects against obesity and adipose tissue inflammation in mice Circulation 2014;129(23):2414–25.
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Dr Yung-Chih Chen,A novel mouse model of atherosclerotic plaque instability for drug testing and mechanistic/therapeutic discoveries using gene and microRNA expression profiling Circulation Research 2013;113(3):252–65.
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Dr Yung-Chih Chen,Protective role for Toll-like receptor-9 in the development of atherosclerosis in apolipoprotein E-deficient mice Arteriosclerosis, Thrombosis, and Vascular Biology 2014;34(3):516–25.
