Magdaline Costa
Flow Cytometrist
Life Sciences
Burnet Institute
Australia
Biography
Magdaline Costa joined the AMREPFlow, Core Flow Cytometry Facility in 2017. Prior to this, she was a post-doctoral scientist for 17 years and worked on a range of projects.
Research Interest
She spent most of her postdoctoral career working with human embryonic stem cells (hESCs) and human induced pluripotent stem (iPS) cells. She successfully generated a gene targeting protocol and differentiated these cells into endothelium. Recently, iPS cells generated from patients with acute myeloid leukaemia (AML) were used to investigate this disease in vitro.
Publications
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GAPTrap: A Simple Expression System for Pluripotent Stem Cells and Their Derivatives. Kao T, Labonne T, Niclis JC, Chaurasia R, Lokmic Z, Qian E, Bruveris FF, Howden SE, Motazedian A, Schiesser JV, Costa M, Sourris K, Ng E, Anderson D, Giudice A, Farlie P, Cheung M, Lamande SR, Penington AJ, Parish CL, Thomson LH, Rafii A, Elliott DA, Elefanty AG, Stanley EG Stem Cell Reports. 2016 Sep; 7(3):518-526
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Differentiation of human embryonic stem cells to HOXA+ hemogenic vasculature that resembles the aorta-gonad-mesonephros. Ng ES, Azzola L, Bruveris FF, Calvanese V, Phipson B, Vlahos K, Hirst C, Jokubaitis VJ, Yu QC, Maksimovic J, Liebscher S, Januar V, Zhang Z, Williams B, Conscience A, Durnall J, Jackson S, Costa M, Elliott D, Haylock DN, Nilsson SK, Saffery R, Schenke-Layland K, Oshlack A, Mikkola HK, Stanley EG, Elefanty AG Nat Biotechnol. 2016 Nov; 34(11):1168-1179
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Oncogenic ZEB2 activation drives sensitivity towards KDM1A inhibition in T-cell acute lymphoblastic leukemia. Goossens S, Peirs S, Van Loocke W, Wang J, Takawy M, Matthijssens F, Sonderegger SE, Haigh K, Nguyen T, Vandamme N, Costa M, Carmichael C, Van Nieuwerburgh F, Deforce D, Kleifeld O, Curtis DJ, Berx G, Van Vlierberghe P, Haigh JJ Blood. 2017 Jan; Epub ahead of print
