R. Scott Lokey
Co-Founder and SAB Chairman
Chemistry
Circle Pharma, Inc
Australia
Biography
R. Scott Lokey, Ph.D., has been a faculty member in the department of Chemistry and Biochemistry at the University of California Santa Cruz since 2002. He received a B.S. in chemistry from Trinity University in San Antonio, Texas, and a Ph.D. in bioorganic chemistry from University of Texas, Austin in bioorganic chemistry. Scott held a NIH postdoctoral fellowship at the Harvard Institute of Chemistry and Cell Biology, where he worked on the identification of cyclic peptide modulators of actin dynamics. His current research interests include the basic science underlying cell permeability of cyclic peptides, and the development of methodologies for synthesizing libraries of cyclic peptides for the discovery of bioactive ligands against intracellular targets. Scott and Matt Jacobson have collaborated for more than a decade on the application of computational approaches for predicting membrane permeability in "beyond Rule-of-5" molecules, with a particular focus on macrocyclic peptides.
Research Interest
His current research interests include the basic science underlying cell permeability of cyclic peptides, and the development of methodologies for synthesizing libraries of cyclic peptides for the discovery of bioactive ligands against intracellular targets. Scott and Matt Jacobson have collaborated for more than a decade on the application of computational approaches for predicting membrane permeability in "beyond Rule-of-5" molecules, with a particular focus on macrocyclic peptides.
