Catherine Abbott
Associate Professor
College of Science and Engineering, Biological Sciences
Flinders University
Australia
Biography
Dr Abbott received her Ph.D from the University of Sydney in 1997 during which she cloned and sequenced the gene for the protease dipeptidyl peptidase 4 (DPP4) in the pre- human genome era. Her discovery of the protease homologues, DPP8 and DPP9 during her post-doctoral studies at the Centenary Institute, Sydney was pivotal to translating selective DPP4 inhibitors such as Sitagliptin safely from the laboratory to the clinic for the treatment of Type 2 diabetes. In 2001, she moved to the School of Biological Sciences, Flinders University, where she has maintained her passion for this family working on their structure and function using DPP inhibitors and DPP substrate discovery to study the role of these proteases in diseases such as cancer, inflammation and metabolism. She is internationally recognized as an expert in the DPP field and is a member of the Flinders Centre for Innovation in Cancer.
Research Interest
Biochemistry and cell biology Clinical sciences Oncology and carcinogenesis
Publications
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Wilson, C.H. and Abbott, C.A. (2012). Expression profiling of dipeptidyl peptidase 8 and 9 in breast and ovarian carcinoma cell lines. International Journal of Oncology, 41(3) pp. 919-932.
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Wilson, C.H., Indarto, D., Doucet, A., Pogson, L.D., Pitman, M., McNicholas, K., et al. (2013). Identifying natural substrates for dipeptidyl peptidases 8 and 9 using terminal amine isotopic labeling of substrates (TAILS) reveals in vivo roles in cellular homeostasis and energy metabolism. Journal of Biological Chemistry, 288(20) pp. 13936-13949.
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Laffy, P., Benkendorff, K. and Abbott, C.A. (2013). Suppressive subtractive hybridization transcriptomics provides a novel insight into the functional role of the hypobranchial gland in a marine mollusc. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 8(2) pp. 111-122.
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Yazbek, R., Jaenisch, S.E. and Abbott, C.A. (2017). Potential Disease Biomarkers: Dipeptidyl Peptidase 4 and Fibroblast Activation Protein. PROTOPLASMA,
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Munawara, U., Small, A.G., Quach, A., Gorgani, N., Abbott, C.A. and Ferrante, A. (2017). Cytokines regulate complement receptor immunoglobulin expression and phagocytosis of Candida albicans in human macrophages: A control point in anti-microbial immunity. Scientific Reports, 7(1) pp. Art: 4050.
