Mark Febbraio
Professor
Diabetes and Metabolism
Garvan Institute of Medical Research
Australia
Biography
Prof Mark Febbraio is a Senior Principal Research Fellow of the NHMRC, is the Head of the Cellular and Molecular Metabolism Laboratory and Head of the Diabetes and Metabolism Division at the Garvan Institute for Medical Research. He is also the Chief Scientific Officer of N-Gene Research Laboratories Inc, a USA based Biotechnology Company.
Research Interest
• Obesity and insulin resistance • Cytokine signalling • Inflammation • Exercise Metabolism
Publications
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Sapra G, Tham YK, Cemerlang N, Matsumoto A, Kiriazis H, Bernardo BC, Henstridge DC, Ooi JYY, Pretorius L, Boey EJH, Lim L, Sadoshima J, Meikle PJ, Mellet NA, Woodcock EA, Marasco S, Ueyama T, Dy X-J, Febbraio MA*, & McMullen JR*. The small molecule, BGP-15, protects against heart failure and atrial fibrillation in mice. Nature Comm. DOI: 10.1038/ncomms6705, 2014 . *MAF and JRM are joint corresponding authors. Accompanied by Research Highlight: Crunkthorn S. Insulin sensitizer protects the heart. Nature Rev Drug Disc. 14 (2): 93, 2014
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Mauer J, Chaurasia B, Goldau J, Vogt MC, Schmitz J, Ruud J, Nguyen KD, Theuric S, Hausen C, Bronneke HS, Estevez, E, Allen TL, Febbraio MA, Chawla A, Wunderlich FT, & Breuning JC. IL-6 signaling in myeloid cells promotes alternative macrophage activation to limit obesity-associated insulin resistance. Nature Immunol. 15: 423-430, 2014. Accompanied by Research Highlights: Reilly SM, Saltiel AR. Countering inflammatory signals in obesity. Nature Immunol. 15: 410-411, 2014; Covarrabias AJ, Horng T. IL-6 strikes a balance in metabolic inflammation. Cell Metab. 19: 898-899, 2014; Bordon Y. Immunometabolism: IL-6 the resistance fighter. Nature Rev Immunol. 14: 282-283, 2014.
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Kraakman MJ, Kammoun HL, Allen TL, Deswaerte V, Henstridge DC, Estevez E, Matthews VB, Neill B, White DA, Murphy AJ, Peijs L, Yang C, Rises S, Bruce CR, Du X-J, Bobik A, Lee-Young RS, Kingwell BA, Vasanthakumar A, Shi W, Kallies A, Lancaster GI, Rose-John S, & Febbraio MA. Blocking IL-6 trans-signaling prevents high fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance. Cell Metab. 21:403-416, 2015.
