Stuart Tangye
Professor
Immunology Division
Garvan Institute of Medical Research
Australia
Biography
Professor Stuart Tangye completed his PhD on B-cell leukemia under the supervision of Prof Bob Raison at the University of Technology Sydney in 1995 and then undertook postdoctoral training at the DNAX Research Institute for Molecular and Cellular Biology (Palo Alto California, USA; 1996-1999) in the laboratories of Drs Jan de Vries, Joe Phillips and Lewis Lanier. It was during this time that his passion for human immunology, cell biology and immune deficiencies was ignited. He returned to Australia in 2000 as a University of Sydney Research Fellow to work with Dr Phil Hodgkin at the Centenary Institute of Cancer Medicine and Cell Biology (University of Sydney). He established his own independent research lab in 2002, and was recruited to the Garvan Institute in 2006. Since 1995, he has published >100 peer-reviewed research articles and invited reviews. In 2011, he received the Gottschalk Medal from the Australian Academy of Sciences, which recognises “outstanding research in the medical sciences by scientists no more than 40 years of age”. In addition to overseeing his own research lab, he serves as the Deputy Editor of the journal Immunology & Cell Biology, as an Associate Editor of Journal of Immunology, and an Advisory Editor for the Journal of Experimental Medicine. He is regularly invited to present his latest findings at numerous international immunology conferences. The Tangye lab has been supported by Research Fellowships and Program and Project grants awarded by the NHMRC, Cancer Council NSW, Association for International Cancer Research (UK), XLP Research Trust (UK) and the Cancer Institute NSW.
Research Interest
Human immunology and immunodeficiency Transcriptional regulation of lymphocyte function Cytokine biology Pathogenesis of human immunological diseases Infectious susceptibility in human primary immunodeficiencies
Publications
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Abolhassani H, Edwards ES, Ikinciogullari A, Jing H, Borte S, Buggert M, Du L, Matsuda-Lennikov M, Romano R, Caridha R, Bade S, Zhang Y, Frederiksen J, Fang M, Bal SK, Haskologlu S, Dogu F, Tacyildiz N, Matthews HF, McElwee JJ, Gostick E, Price DA, Palendira U, Aghamohammadi A, Boisson B, Rezaei N, Karlsson AC, Lenardo MJ, Casanova JL, Hammarström L, Tangye SG, Su HC, Pan-Hammarström Q. Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency. J Exp Med. (January 2017) 214(1):91-106.
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Tangye SG. Pathogenic CD4+ T cells regulating B-cell differentiation in autoimmunity: not exactly Tfh cells. Immunol Cell Biol. (May 2017) 95(5):419-421
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Cottineau J, Kottemann MC, Lach FP, Kang YH, Vély F, Deenick EK, Lazarov T, Gineau L, Wang Y, Farina A, Chansel M, Lorenzo L, Piperoglou C, Ma CS, Nitschke P, Belkadi A, Itan Y, Boisson B, Jabot-Hanin F, Picard C, Bustamante J, Eidenschenk C, Boucherit S, Aladjidi N, Lacombe D, Barat P, Qasim W, Hurst JA, Pollard AJ, Uhlig HH, Fieschi C, Michon J, Bermudez VP, Abel L, de Villartay JP, Geissmann F, Tangye SG, Hurwitz J, Vivier E, Casanova JL, Smogorzewska A, Jouanguy E. Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency. J Clin Invest. (May 2017) 1;127(5):1991-2006
