Susan Clark
Professor
Genomics and Epigenetics
Garvan Institute of Medical Research
Australia
Biography
Susan completed her BSc (Hons1) degree at the Australian National University, ACT, Australia in 1978 and graduated in 1982 with a PhD in Biochemistry, University of Adelaide, South Australia, mapping and sequencing human histone genes, under the supervision of Dr Julian Wells. Susan spent her postdoctoral years at Biotechnology Australia from 1983-1988 leading studies on recombinant vaccine development and eukaryotic expression of human inhibin, Il-3 and GMCSF. In 1992, she returned to basic research as Group Leader of the Gene Regulation Unit at the Kanematsu Laboratories, Royal Prince Alfred Hospital where she developed and implemented bisulphite sequencing for DNA methylation analysis. In 2000, she established and headed the Epigenetics Group at the Sydney Cancer Centre, Royal Prince Alfred Hospital and in 2004 moved her group to the Garvan Institute of Medical Research and initiated and led the growth of the Epigenetics Research Program in the Cancer Research Division.
Research Interest
Bioinformatics Cancer Research Chromatin Disease Mechanisms DNA methylation Epigenetics Gene Expression Molecular Genetics Next Generation Sequencing
Publications
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Frigola J, Song J, Stirzaker C, Hinshelwood RA, Peinado MA and Clark SJ (2006). Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band. Nat Genet 38: 540-549.
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Coolen MW, Stirzaker C, Song JZ, Statham AL, Kassir Z, Moreno CS, Young AN, Varma V, Speed TP, Cowley M, Lacaze P, Kaplan W, Robinson MD and Clark SJ. Consolidation of the cancer genome into domains of repressive chromatin by long-range epigenetic silencing (LRES) reduces transcriptional plasticity. Nat Cell Biol 2010; 12:235-246.
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Hinshelwood RA, Huschtscha LI, Melki J, Stirzaker C, Abdipranoto A, Vissel B, Ravasi T, Wells CA, Hume DA, Reddel RR and Clark SJ. Concordant epigenetic silencing of transforming growth factor-beta signaling pathway genes occurs early in breast carcinogenesis. Cancer Res 2007; 67:11517-11527.
