Bryan Williams
Professor
Centre for Cancer Research
Hudson Institute of Medical Research
Australia
Biography
Professor Bryan Williams is Emeritus Director and Distinguished Scientist at the Hudson Institute of Medical Research. He is also Program Director of the Paediatric Precision Medicine program. A distinguished researcher and international authority on innate immunity and cancer biology, Professor Williams has made major contributions to our understanding of the antiviral mechanisms of actions of interferons, advancing their therapeutic utility.
Research Interest
His discoveries in the 2-5A-RNaseL pathway, cloning and characterisation of protein kinase R, and signalling pathways activated by interferons and innate immune activation by small interfering RNAs, have opened new therapeutic opportunities.
Publications
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Sigson EAW, Williams BRG (2017) An emergence framework of carcinogenesis. Front Oncol 7:198.
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Dou Y, Yim HCH, Kirkwood CD, Williams BRG, Sadler AJ (2017) The innate immune receptor MDA5 limits rotavirus infection but promotes cell death and pancreatic inflammation. EMBO J 36:2742-2757.
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Ahmed AU, Yim HCH, Alorro M, Ernst M, Williams BRG (2017) Integrin-linked kinase expression in myeloid cells promotes inflammatory signaling during experimental colitis. J Immunol 199:2128-2139.
