Dr Anthony Sadler
Research Group Head
Centre for Cancer Research
Hudson Institute of Medical Research
Australia
Biography
Dr Sadler is expert in innate immunity. After completing his early research training in microbial genetics at the University of Canterbury and virology at the University of Otago he travelled to the US where he conducted postdoctoral research into host immune responses to microbial pathogens at the Centre for Cancer Biology within the Learner Research Institute. In 2007, Dr Sadler came to Australia where he took up a position as a Senior Research Fellow within the Hudson Institute’s Centre for Cancer Research. He subsequently moved to the Centre for Innate Immunity and Infectious Disease within the same institute. His research group investigates innate immune responses that drive inflammation.
Research Interest
Dr Sadler’s research has advanced our knowledge of the regulation of cell signalling pathways that control responses to our environment. His research aims to characterise mechanisms that cause inflammation to be able to identify strategies to curb inflammatory pathologies and ensuing disease.
Publications
-
Sadler AJ et al. The Acetyltransferase HAT1 Moderates the NF-kB Response by Regulating the Transcription Factor PLZF (ZBTB16). Nat. Comm., 13;6:6795, 2015.
-
Sadler AJ et al. The BTB-ZF transcriptional regulator, PLZF (ZBTB16), modifies chromatin to restrain inflammatory signaling programs. Proc Natl Acad Sci USA, 112(5):1535-40, 2015.
-
Yim HCH, Wang D, Yu L, White CL, Faber PW, Williams BRG and Sadler AJ. The kinase activity of PKR represses inflammasome activity. Cell Reports in press 2015.
