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Reproductive Medicine Experts

Dr Graeme Polglase

Research Group Head
The Ritchie Centre
Hudson Institute of Medical Research
Australia

Biography

An internationally recognised physiologist, Dr Polglase is a leading authority on the role of pulmonary, cardiovascular, and cerebral circulation in organ inflammation and injury in preterm and compromised infants. A Monash University Graduate, he completed his PhD in 2005. Dr Polglase was recruited to join the Department of Women’s and Infants’ Health, the University of Western Australia, Perth, WA, which was running the largest perinatal ovine research program in the world. Following his promotion to manager in 2008, he took over primary responsibility for running all animal studies. In 2010, Dr Polglase joined The Ritchie Centre where he established the Perinatal Transition Research Group in 2011 to influence clinical practice in the management of preterm and compromised infant care. Translation of his findings continues to improve treatment outcomes as evidenced by his publications cited in Australian, European, and International resuscitation guidelines, and multiple invitations to speak at national and international clinical meetings.

Research Interest

Premature birth is the single greatest cause of neonatal morbidity and mortality. Dr Polglase is working to improve the respiratory, cardiovascular, and neurological outcomes of infants born preterm. His findings continue to expand the understanding of how key events during fetal development, birth, and post-delivery influence the pulmonary, cardiovascular and cerebral systems of preterm babies. He hopes this work will reduce the incidence of organ inflammation and injury, in order to improve outcomes for some of our tiniest patients.

Publications

  • Polglase G.R., Barton S.K., Melville J.M., Zahra V., Wallace M.J., Siew M.L., Tolcos M. and Moss T.J.M. Prophylactic erythropoietin exacerbates ventilation-induced lung inflammation and injury in preterm lambs. J Physiol. 2014 May 1;592(Pt 9):1993-2002.

  • Skiold B., Hooper S.B., Wu Q., Hooper S.B., Davis P.G., McIntyre R.2, Tolcos M., Pearson J., Vreys R., Egan G.F., Barton S.K., Cheong J.L.Y. Polglase G.R. Early detection of ventilation-induced brain injury using magnetic resonance spectroscopy and diffusion tensor imaging: an in vivo study in preterm lambs. PLoS One. 2014 Apr 23;9(4):e95804.

  • Polglase G.R., Miller S. L., Barton S. K., Kluckow M.,Gill A.W.,Hooper S.B. and Tolcos M. Respiratory support for premature neonates in the delivery room: potential effects on cardiovascular function and brain injury. Invited Review. Pediatr Res. 2014 Jun;75(6):682-8.

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