Dr Matthew Mckenzie
Research Group Head
Centre for Genetic Diseases
Hudson Institute of Medical Research
Australia
Biography
Following the completion of his PhD in 2002, Dr Matthew McKenzie undertook his postdoctoral research in the laboratory of Professor Michael Duchen, University College London. There he investigated how mitochondrial membrane potential, calcium handling and ATP generation are disrupted in mitochondrial disorders using state-of-the-art confocal imaging techniques. In 2004, Dr McKenzie returned to Australia to work in Professor Michael Ryan’s laboratory at Melbourne’s La Trobe University. During this time, he received an NHMRC Peter Doherty Fellowship, and subsequently an NHMRC Career Development Fellowship, to study the biogenesis of mitochondrial complex I and how inherited defects can disrupt this process. In April 2011, Dr McKenzie was recruited by Hudson Institute of Medical Research as a Research Group Leader in the Centre for Genetic Diseases.
Research Interest
His current research focuses on interactions between protein complexes involved in mitochondrial fatty acid beta-oxidation (FAO) and oxidative phosphorylation (OXPHOS), and their importance in human disease pathology.
Publications
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Cagnone GL, Tsai TS, Makanji Y, Matthews P, Gould J, Bonkowski MS, Elgass KD, Wong AS, Wu LE, McKenzie M, Sinclair DA, St. John JC (2016) Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency. Sci Rep, 6:23229.
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Kang Y, Baker MJ, Liem M, Louber J, McKenzie M, Atukorala I, Ang CS, Keerthikumar S, Mathivanan S, Stojanovski D (2016) Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability. Elife, 24;5 pii: e17463.
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Lim SC, Hroudová J, Van Bergen NJ, Lopez Sanchez MI, Trounce IA, McKenzie M (2016) Loss of the Mitochondrial DNA-encoded protein ND1 results in the disruption of Complex I biogenesis during the early stages of its assembly. FASEB J, 30:2236-48.
