Dr Sarah Paule
Research Scientist
Centre for Reproductive Health
Hudson Institute of Medical Research
Australia
Biography
Dr Paule completed her PhD at Monash University in the Department of Biochemistry and Molecular Biology in 2006. Following her PhD, Dr Paule spent two years as a postdoctoral scientist at DiaB-tech, a drug development company in Melbourne. In 2009, she joined the Hudson Institute of Medical Research and changed her research field to reproductive biology within the Implantation and Placental Development Laboratory headed by Professor Guiying Nie. This laboratory is renowned for its research on uterine factors that contribute to the success or failure of embryo implantation and placental development.
Research Interest
Dr Paule’s research focuses on the remodelling of endometrium and, in particular, the epithelial cell surface which is the first point of contact between the embryo and endometrium. She is also interested in how progesterone regulates cell surface proteins for endometrial epithelial receptivity for embryo implantation and the pregnancy establishment.
Publications
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Ho H, Singh H, Heng S, Nero TL, Paule S, Parker MW, Johnson AT, Jiao GS, Nie G (2013) Small molecule proprotein convertase inhibitors for inhibition of embryo implantation. PLoS One 8(12):e81380.
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Paule S, Nebl T, Webb AL, Vollenhoven B, Rombauts LJF, Nie G (2015) Proprotein convertase 5/6 cleaves platelet derived growth factor A in the human endometrium in preparation for embryo implantation. Mol Hum Reprod 21:262-270.
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Heng S, Paule SG, Li Y, Rombauts LJ, Vollenhoven B, Salamonsen LA, Nie G (2015) Posttranslational removal of α-dystroglycan N terminus by PC5/6 cleavage is important for uterine preparation for embryo implantation in women. FASEB . 29(9):4011-22.
