Dr Sylvia Mahara
Postdoctoral Scientist
Centre for Cancer Research
Hudson Institute of Medical Research
Australia
Biography
Dr Sylvia Mahara completed her PhD in Cancer Biology jointly at Cancer Science Institute of Singapore and Genome Institute of Singapore in early 2016. On the completion of her PhD, she joined Hudson Institute for her postdoctoral training, where she was awarded a US Department of Defense Peer Reviewed Cancer Horizon award in early 2017. The Horizon Award supports junior-level scientists to conduct impactful cancer research with the mentorship of an experienced cancer researcher.
Research Interest
Dr Mahara’s current research focuses primarily on the dysregulated epigenetic signalling in colorectal cancer, which is a key early event of colorectal cancer development. She utilises genome editing technology targeting nearly ~700 cancer-associated epigenetic regulators, in an effort to dissect their molecular mechanism in the early events of tumourigenesis. She believes that a good understanding of the epigenetic landscape may facilitate the development of targeted treatments to potentially reverse the disease progression.
Publications
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Mahara S, Lee PL, Feng M, Tergaonkar V, Chng WJ, Yu Q (2016) HIFI-alpha activation underlies a functional switch in the paradoxical role of Ezh2/PRC2 in breast cancer. Proc Natl Acad Sci U S A 113: E3735-3744.
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Mahara S, Firestein R (2017) Targeting the seeds of small cell lung cancer. Ann Transl Med 5:113.
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Mahara S, Chng WJ, Yu Q (2016) Molecular Switch of EZH2 in Hypoxia. Cell Cycle 15:3007-3008.
