Dr Vijesh Vaghjiani
Postdoctoral Scientist
Centre for Cancer Research
Hudson Institute of Medical Research
Australia
Biography
Dr Vijesh Vaghjiani’s research program focuses on understanding the oncogenic roles of embryonic signalling pathways in cancer. Particular interest is in the Hedgehog signalling pathway that is strongly implicated in a variety of both paediatric and adult cancers.
Research Interest
Dr Vaghjiani’s work utilizes robust in vitro and in vivo preclinical models of Hedgehog-dependent cancer to investigate the mechanisms leading to tumorigenesis and progression as well as the identification and validation of biomarkers and specific pathway inhibitors.
Publications
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Johnson J, Lee W, Frazier AE, Vaghjiani V, Laskowski A, Rodriguez AL, Cagnone G, McKenzie M, White SJ, Nisbet DR, Thorburn DR, St John JC (2016) Deletion of the complex I subunit NDUFS4 adversely modulates cellular differentiation. Stem Cells Dev 25:239-250.
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Fleuren EDG, Vlenterie M, van der Graf WTA, Hillebrandt-Roeffen MHS, Blackburn J, Ma Xiuquan, Chan H, Magias MC, van Erp A, van Houdt L, Cebeci SAS, van de Ven A, Flucke UE, Heyer EE, Thomas D, Lord CJ, Marini KD, Vaghjiani V, Mercer TR, Cain JE, Wu J, Versleijen-Jonkers YMH, Daly RJ (2017) Phosphoproteomic profiling across sarcoma subtypes reveals ALK and MET as novel actionable targets in synovial sarcomas. Cancer Res77:4279-4292.
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Vaghjiani V, Cain JE, Lee W, Vaithilingam V, Tuch BE, St John JC (2017) Modulation of Mitochondrial DNA Copy Number to Induce Hepatocytic Differentiation of Human Amniotic Epithelial Cells. Stem Cells Dev 26:1505-1519.
