Jason Cain
Research Group Head
Centre for Cancer Research
Hudson Institute of Medical Research
Australia
Biography
Dr Jason Cain is Head of the Developmental and Cancer Biology research group in Hudson Institute’s Centre for Cancer Research and a Chief Investigator for the Paediatric Precision Medicine Program. A developmental and cancer biologist, Dr Cain is driving cutting-edge research to understand the role of critical embryonic signalling pathways and epigenetic mechanisms in normal and abnormal development and disease, including paediatric connective tissue (sarcomas) and brain cancers (including atypical teratoid rhabdoid tumours, medulloblastoma and diffuse intrinsic pontine glioma). After completing his PhD studies at Monash University in 2006, Dr Cain moved to The Hospital for Sick Children in Toronto, Canada to complete postdoctoral training with Dr Norman Rosenblum in the Program of Developmental and Stem Cell Biology.
Research Interest
He focused on the role of the Hedgehog signalling pathway in renal development and disease, developing specialised skills in developmental biology, mouse models of human disease, and congenital and paediatric disease.
Publications
-
Muscat A, Popovski D, Jayasekara WSN, Rossello FJ, Alamgeer M, Algar EM, Ferguson M, Watkins DN, Cain JE, Ashley DM (2016) Low-Dose Histone Deacetylase Inhibitor Treatment Leads to Tumour Growth Arrest and Multi-lineage Differentiation of Malignant Rhabdoid Tumours. Clinical Cancer Research 22:3560-3570.
-
Fleuren EDG, Vlenterie M, van der Graf WTA, Hillebrandt-Roeffen MHS, Blackburn J, Ma Xiuquan, Chan H, Magias MC, van Erp A, van Houdt L, Cebeci SAS, van de Ven A, Flucke UE, Heyer EE, Thomas D, Lord CJ, Marini KD, Vaghjiani V, Mercer TR, Cain JE, Wu J, Versleijen-Jonkers YMH, Daly RJ (2017) Phosphoproteomic profiling reveals ALK and MET as novel actionable targets across synovial sarcoma subtypes. Cancer Research
-
Szczepny A, Rogers S, Jayasekara WSN, Park K, McCloy RA, Cochrane CR, Ganju V, Cooper WA, Sage J, Peacock CD, Cain JE, Burgess A, Watkins DN (2017) The Role of Canonical and Non-Canonical Hedgehog Signaling in Tumor Progression in a Mouse Model of Small Cell Lung Cancer. Oncogene.
