Niamh Mangan
Research Scientist
Centre for Innate Immunity and Infectious Diseases
Hudson Institute of Medical Research
Australia
Biography
Dr Niamh Mangan is a research scientist and emerging expert in immunology of infections and inflammation. After completing her PhD at Trinity College Dublin, Ireland under the supervision of Professor Padraic Fallon, Dr Mangan travelled to Australia where she undertook postdoctoral training with Professor Paul Hertzog from 2008. In 2010, Dr Mangan was awarded a prestigious Australian Research Council Fellowship, as well as a New Investigator award by the National Health and Medical Research Council.
Research Interest
Her research interests lie primarily in understanding cellular mechanisms of modulation and suppression of the immune response in infections and inflammation. Her current research examines the role of interferon, cytokine and receptor signalling in immune regulation, in particular characterising the novel cytokine interferon epsilon (IFNε) in the regulation of mucosal immune responses.
Publications
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Nold-Petry CA, Lo CY, Rudloff I, Elgass KD, Li S, Gantier MP, Lotz-Havla AS, Gersting SW, Cho SX, Lao JC, Ellisdon AM, Rotter B, Azam T, Mangan NE, Rossello FJ, Whisstock JC, Bufler P, Garlanda C, Mantovani A, Dinarello CA, Nold MF (2015) IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction. Nat Immunol 16:354-365.
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Eid SG, Mangan NE, Hertzog PJ, Mak J (2015) Blocking HIV-1 transmission in the female reproductive tract: from microbicide development to exploring local antiviral responses. Clin Transl Immunol 4:e43.
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Cottle DL, Ursino GM, Ip SC, Jones LK, Ditommaso T, Hacking DF, Mangan NE, Mellett NA, Henley KJ, Sviridov D, Nold-Petry CA, Nold MF, Meikle PJ, Kile BT, Smyth IM (2015) Fetal inhibition of inflammation improves disease phenotypes in harlequin ichthyosis. Hum Mol Genet 24:436-449.
